Results 51 to 60 of about 10,802,441 (400)

Role of Oxidative Stress in Heart Failure: Insights from Gene Transfer Studies

Biomedicines, 2021
Under physiological circumstances, there is an exquisite balance between reactive oxygen species (ROS) production and ROS degradation, resulting in low steady-state ROS levels.
Bart De Geest, Mudit Mishra
doaj   +1 more source

Safety and efficacy of gene transfer for Leber's congenital amaurosis.

New England Journal of Medicine, 2008
Leber's congenital amaurosis (LCA) is a group of inherited blinding diseases with onset during childhood. One form of the disease, LCA2, is caused by mutations in the retinal pigment epithelium-specific 65-kDa protein gene (RPE65).
A. Maguire, F. Simonelli, E. Pierce, E. Pugh, F. Mingozzi, J. Bennicelli, S. Banfi, Kathleen A. Marshall, F. Testa, E. Surace, S. Rossi, A. Lyubarsky, V. Arruda, B. Konkle, E. Stone, Junwei Sun, J. Jacobs, L. Dell’Osso, R. Hertle, Jian-xing Ma, T Michael Redmond, Xiaosong Zhu, B. Hauck, O. Zelenaia, K. Shindler, M. Maguire, J. F. Wright, N. Volpe, J. McDonnell, A. Auricchio, K. High, J. Bennett   +31 more
semanticscholar   +1 more source

Geographic variation in walking activity in the red flour beetle Tribolium castaneum

Population Ecology, EarlyView.
This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley   +1 more source

Adenovirus-associated virus vector-mediated gene transfer in hemophilia B.

New England Journal of Medicine, 2011
BACKGROUND Hemophilia B, an X-linked disorder, is ideally suited for gene therapy. We investigated the use of a new gene therapy in patients with the disorder.
A. Nathwani, E. Tuddenham, S. Rangarajan, Cecilia Rosales, J. McIntosh, D. Linch, P. Chowdary, A. Riddell, Arnulfo Pie, C. Harrington, J. O’Beirne, Keith A. Smith, J. Pasi, B. Glader, P. Rustagi, C. Ng, M. Kay, Junfang Zhou, Yunyu Spence, C. Morton, J. Allay, J. Coleman, S. Sleep, J. Cunningham, D. Srivastava, E. Basner-Tschakarjan, F. Mingozzi, K. High, J. Gray, U. Reiss, A. Nienhuis, A. Davidoff   +31 more
semanticscholar   +1 more source

Endosymbiotic Gene Transfer and Transcriptional Regulation of Transferred Genes in Paulinella chromatophora [PDF]

Molecular Biology and Evolution, 2010
Paulinella chromatophora is a cercozoan amoeba that contains "chromatophores," which are photosynthetic inclusions of cyanobacterial origin. The recent discovery that chromatophores evolved independently of plastids, underwent major genome reduction, and transferred at least two genes to the host nucleus has highlighted P.
Arthur R. Grossman, Michael Melkonian, Heiko Vogel, Gernot Glöckner, Eva C. M. Nowack, Eva C. M. Nowack, Marco Groth   +6 more
openaire   +4 more sources

A reservoir of 'historical' antibiotic resistance genes in remote pristine Antarctic soils [PDF]

, 2018
Background: Soil bacteria naturally produce antibiotics as a competitive mechanism, with a concomitant evolution, and exchange by horizontal gene transfer, of a range of antibiotic resistance mechanisms.
Bezuidt, Oliver KI, Cowan, Don A, Makhalanyane, Thulani P, Pierneef, Rian, Van de Peer, Yves, Van Goethem, Marc W   +5 more
core   +2 more sources

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

FEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta, Agnieszka Katarzyna Maciola, Tania Baccega, Giulia Pasqual   +3 more
wiley   +1 more source

Efficient Gene Transfer and Gene Editing in Sterlet (Acipenser ruthenus)

Frontiers in Genetics, 2018
The sturgeon (Acipenseriformes) is an important farmed species because of its economical value. However, neither gene transfer nor gene editing techniques have been established in sturgeon for molecular breeding and gene functional study until now.
Ji Chen, Wei Wang, Zhaohui Tian, Ying Dong, Tian Dong, Hua Zhu, Zuoyan Zhu, Hongxia Hu, Wei Hu, Wei Hu   +9 more
doaj   +1 more source

Cotton Biotechnology: An Efficient Gene Transfer Protocol via Agrobacterium tumefaciens for a Greater Transgenic Recovery

Journal of Natural Fibers, 2022
Due to its economic worth, cotton (Gossypium hirsutum L.) is grown in almost 70 countries and provides income for more than 250 million people. Therefore, producing cotton with having some desired characteristics that includes extended biotic and abiotic
Ibrahim Ilker Ozyigit, Ilhan Dogan, Yilmaz Kaya, Kasim Bajrovic, Nermin Gozukirmizi   +4 more
doaj   +1 more source

Horizontal Gene Transfer and the History of Life.

Cold Spring Harbor Perspectives in Biology, 2016
Microbes acquire DNA from a variety of sources. The last decades, which have seen the development of genome sequencing, have revealed that horizontal gene transfer has been a major evolutionary force that has constantly reshaped genomes throughout ...
V. Daubin, G. Szöllősi
semanticscholar   +1 more source