Results 81 to 90 of about 5,395,678 (315)
eLife, 2017 Targeting conserved and essential processes is a successful strategy to combat enemies. Remarkably, the clinically important Staphylococcus aureus pathogenicity islands (SaPIs) use this tactic to spread in nature.
Janine Bowring +9 more
doaj +1 more source
Horizontal gene transfer and evolution of antibiotic gene clusters [PDF]
Genome sequencing projects from diverse bacteria and the release of genetically engineered microorganisms make the topic of horizontal gene transfer (HGT) fashionable.
Kallifidas, Dimitrios
core
Oligopeptide-mediated gene transfer into mouse corneal endothelial cells: Expression, design optimization, uptake mechanism and nuclear localization [PDF]
, 2009 Copyright © The Author 2009. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses?by-nc/2.0/uk/) which permits ...
Seow, WY, George, AJT, Yang, Y-Y
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Molecular Therapy: Methods & Clinical Development, 2017 Gene-modified B cells expressing immunoglobulin G (IgG) fusion proteins have been shown to induce tolerance in several autoimmune and other disease models.
Xiaomei Wang +6 more
doaj +1 more source
Gene transfer into mouse lyoma cells by electroporation in high electric fields [PDF]
, 1982 Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH. Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO Journal. 1982;1(7):841-845.Electric impulses (8 kV/cm, 5 microseconds) were found to increase greatly the uptake ...
Hofschneider, P. H. +3 more
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
AntibioticsAntimicrobial resistance (AMR), recognized as one of the top ten global public health threats, is projected to cause around 10 million deaths annually by 2050.
Dimitris C. Kounatidis +9 more
doaj +1 more source
The state-of-the-art of grapevine biotechnology and new breeding technologies (NBTS)
OENO One, 2019 Context of the review: The manipulation of the genetic basis controlling grapevine adaptation and phenotypic plasticity can be performed either by classical genetics or biotechnologies.
Lorenza Dalla Costa +6 more
doaj +1 more source
Staphylococcus aureus temperate bacteriophage: carriage and horizontal gene transfer is lineage associated. [PDF]
, 2012 Staphylococcus aureus is a major cause of human and animal infections. Bacteriophage are a class of mobile genetic element (MGE) that carry virulence genes and disseminate them horizontally, including Panton-Valentine leukocidin (PVL), the immune evasion
McCarthy, AJ +8 more
core +1 more source