Results 1 to 10 of about 7,756,484 (416)

The thermodynamics of general anesthesia [PDF]

Biophys. J. 92 (2007) 3159-3165, 2006
It is known that the action of general anesthetics is proportional to their partition coefficient in lipid membranes (Meyer-Overton rule). This solubility is, however, directly related to the depression of the temperature of the melting transition found close to body temperature in biomembranes. We propose a thermodynamic extension of the Meyer-Overton
Abelho, Andrew D. Jackson, Boheim, Cantor, Cantor, Cantor, Cantor, Cruzeiro-Hansson, Ebel, Firestone, Firestone, Franks, Franks, Galla, Halsey, Heimburg, Heimburg, Jain, Johnson, Kamaya, Kaminoh, Kaminoh, Katz, Kendig, Kharakoz, Kinnunen, Kobatake, Kreienbühl, Langerman, Lee, Lee, Meyer, Moss, Overton, Papahadjopoulos, Peoples, Punnia-Moorthy, Ritchie, Roth, Silbey, Spyropoulos, Thomas Heimburg, Trudell, Träuble, Träuble, Urban, van de Vossenberg   +46 more
arxiv   +11 more sources

General anesthesia reduces complexity and temporal asymmetry of the informational structures derived from neural recordings in Drosophila [PDF]

Phys. Rev. Research 2, 023219 (2020), 2019
We apply techniques from the field of computational mechanics to evaluate the statistical complexity of neural recording data from fruit flies. First, we connect statistical complexity to the flies' level of conscious arousal, which is manipulated by general anesthesia (isoflurane).
Cohen, Dror, Leung, Angus, Modi, Kavan, Muñoz, Roberto N., Pollock, Felix A., Tsuchiya, Naotsugu, van Swinderen, Bruno, Zecevik, Aidan   +7 more
arxiv   +3 more sources

Stabilizing membrane domains antagonizes n-alcohol anesthesia [PDF]

Biophysical Journal, Volume 111, Issue 3, 9 August 2016, Pages 537-545, 2016
Diverse molecules induce general anesthesia with potency strongly correlated both with their hydrophobicity and their effects on certain ion channels. We recently observed that several n-alcohol anesthetics inhibit heterogeneity in plasma membrane derived vesicles by lowering the critical temperature ($T_c$) for phase separation.
Brooks, NJ, Gray, E, Gray, EM, Machta, BB, McCarthy, NLC, Miller, AL, Nouri, M, Veatch, SL   +7 more
arxiv   +5 more sources

The thermodynamics of general and local anesthesia [PDF]

Biophysical Journal, 2014
General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase.
Graesboll, Kaare, Heimburg, Thomas, Sasse-Middelhoff, Henrike   +2 more
core   +7 more sources

Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults.

New England Journal of Medicine, 2021
BACKGROUND The effects of spinal anesthesia as compared with general anesthesia on the ability to walk in older adults undergoing surgery for hip fracture have not been well studied.
M. Neuman, Rui Feng, J. Carson, Lakisha J. Gaskins, D. Dillane, D. Sessler, F. Sieber, J. Magaziner, E. Marcantonio, S. Mehta, Diane A. Menio, S. Ayad, T. Stone, S. Papp, E. Schwenk, N. Elkassabany, Mitchell H. Marshall, J. D. Jaffe, Charles Luke, B. Sharma, Syed Azim, R. Hymes, K. Chin, R. Sheppard, B. Perlman, J. Sappenfield, E. Hauck, M. Hoeft, Mark Giska, Yatish S Ranganath, T. Tedore, Stephen Choi, Jinlei Li, M. K. Kwofie, A. Nader, R. Sanders, Brian F S Allen, K. Vlassakov, S. Kates, L. Fleisher, James Dattilo, A. Tierney, A. Stephens-Shields, S. Ellenberg   +43 more
semanticscholar   +1 more source

Quality of Recovery After General Anesthesia with Remimazolam in Patients’ Undergoing Urologic Surgery: A Randomized Controlled Trial Comparing Remimazolam with Propofol

Drug Design, Development and Therapy, 2022
Background Remimazolam is a new medication with sedative and hypnotic effects. It has been demonstrated non-inferior to propofol in general anesthesia with regard to efficacy and safety. However, whether general anesthesia with remimazolam is better than
Y. Mao, Jin-He Guo, Jingjing Yuan, Erxian Zhao, Jianjun Yang   +4 more
semanticscholar   +1 more source

Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: The RAGA Randomized Trial.

Journal of the American Medical Association (JAMA), 2021
Importance In adults undergoing hip fracture surgery, regional anesthesia may reduce postoperative delirium, but there is uncertainty about its effectiveness.
Ting Li, Jun Li, Liyong Yuan, Jinze Wu, Chenchen Jiang, Jane Daniels, Rajnikant Mehta, Mingcang Wang, Joyce Yeung, Thomas Jackson, T. Melody, Shengwei Jin, Yinguang Yao, Jimin Wu, Junping Chen, F. G. Smith, Qingquan Lian   +16 more
semanticscholar   +1 more source

Neuraxial and general anesthesia for outpatient total joint arthroplasty result in similarly low rates of major perioperative complications: a multicentered cohort study

Regional anesthesia and pain medicine, 2022
Background Neuraxial anesthesia when compared with general anesthesia has shown to improve outcomes following lower extremity total joint arthroplasty.
E. Yap, Julia C. Wei, Christopher Webb, K. Ng, M. Behrends   +4 more
semanticscholar   +1 more source

Efficacy of stylet angulation at the holding position during tracheal intubation with a videolaryngoscope: a randomized controlled trial

Scientific Reports, 2021
The aim of this randomized controlled trial was to determine the efficacy of stylet angulation at the holding position during tracheal intubation with a McGRATH MAC videolaryngoscope.
Ryo Wakabayashi, Yuki Shiko, Tomofumi Kodaira, Yuko Shiroshita, Hitomi Otsuka, Kosuke Baba, Norimasa Hishinuma   +6 more
doaj   +1 more source

Development and prospective validation of postoperative pain prediction from preoperative EHR data using attention-based set embeddings

npj Digital Medicine, 2023
Preoperative knowledge of expected postoperative pain can help guide perioperative pain management and focus interventions on patients with the greatest risk of acute pain.
Ran Liu, Rodrigo Gutiérrez, Rory V. Mather, Tom A. D. Stone, Laura A. Santa Cruz Mercado, Kishore Bharadwaj, Jasmine Johnson, Proloy Das, Gustavo Balanza, Ekenedilichukwu Uwanaka, Justin Sydloski, Andrew Chen, Mackenzie Hagood, Edward A. Bittner, Patrick L. Purdon   +14 more
doaj   +1 more source