Results 1 to 10 of about 1,366,506 (366)

The thermodynamics of general anesthesia [PDF]

Biophys. J. 92 (2007) 3159-3165, 2006
It is known that the action of general anesthetics is proportional to their partition coefficient in lipid membranes (Meyer-Overton rule). This solubility is, however, directly related to the depression of the temperature of the melting transition found close to body temperature in biomembranes. We propose a thermodynamic extension of the Meyer-Overton
Abelho, Andrew D. Jackson, Boheim, Cantor, Cantor, Cantor, Cantor, Cruzeiro-Hansson, Ebel, Firestone, Firestone, Franks, Franks, Galla, Halsey, Heimburg, Heimburg, Jain, Johnson, Kamaya, Kaminoh, Kaminoh, Katz, Kendig, Kharakoz, Kinnunen, Kobatake, Kreienbühl, Langerman, Lee, Lee, Meyer, Moss, Overton, Papahadjopoulos, Peoples, Punnia-Moorthy, Ritchie, Roth, Silbey, Spyropoulos, Thomas Heimburg, Trudell, Träuble, Träuble, Urban, van de Vossenberg   +46 more
arxiv   +11 more sources

General anesthesia reduces complexity and temporal asymmetry of the informational structures derived from neural recordings in Drosophila [PDF]

Phys. Rev. Research 2, 023219 (2020), 2019
We apply techniques from the field of computational mechanics to evaluate the statistical complexity of neural recording data from fruit flies. First, we connect statistical complexity to the flies' level of conscious arousal, which is manipulated by general anesthesia (isoflurane).
Cohen, Dror, Leung, Angus, Modi, Kavan, Muñoz, Roberto N., Pollock, Felix A., Tsuchiya, Naotsugu, van Swinderen, Bruno, Zecevik, Aidan   +7 more
arxiv   +3 more sources

Stabilizing membrane domains antagonizes n-alcohol anesthesia [PDF]

Biophysical Journal, Volume 111, Issue 3, 9 August 2016, Pages 537-545, 2016
Diverse molecules induce general anesthesia with potency strongly correlated both with their hydrophobicity and their effects on certain ion channels. We recently observed that several n-alcohol anesthetics inhibit heterogeneity in plasma membrane derived vesicles by lowering the critical temperature ($T_c$) for phase separation.
Brooks, NJ, Gray, E, Gray, EM, Machta, BB, McCarthy, NLC, Miller, AL, Nouri, M, Veatch, SL   +7 more
arxiv   +5 more sources

The thermodynamics of general and local anesthesia [PDF]

Biophysical Journal, 2014
General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase.
Graesboll, Kaare, Heimburg, Thomas, Sasse-Middelhoff, Henrike   +2 more
core   +7 more sources

Hypertriglyceridemia induced pancreatitis management – a case report

Journal of the Pakistan Medical Association, 2023
Acute pancreatitis results in high morbidity and mortality. Gallstones and alcoholism are considered leading causes of acute pancreatitis. However, increasing prevalence of obesity, diabetes and lifestyle choices has resulted in Hypertriglyceridemia ...
Aisha Kulsoom Mufti, Naqeeb Ullah, Muhammad Hayat, Muhammad Aimal Khan   +3 more
doaj   +1 more source

Efficacy of stylet angulation at the holding position during tracheal intubation with a videolaryngoscope: a randomized controlled trial

Scientific Reports, 2021
The aim of this randomized controlled trial was to determine the efficacy of stylet angulation at the holding position during tracheal intubation with a McGRATH MAC videolaryngoscope.
Ryo Wakabayashi, Yuki Shiko, Tomofumi Kodaira, Yuko Shiroshita, Hitomi Otsuka, Kosuke Baba, Norimasa Hishinuma   +6 more
doaj   +1 more source

Pharmacodynamic modeling of moderate sedation and rationale for dosing using midazolam, propofol and alfentanil

BMC Pharmacology and Toxicology, 2023
Purpose Regulations have broadened to allow moderate sedation administration for gastrointestinal endoscopy by non-anesthesia personnel. The line between moderate and deep sedation is ambiguous.
Jing-Yang Liou, I-Ting Kuo, Weng-Kuei Chang, Chien-Kun Ting, Mei-Yung Tsou   +4 more
doaj   +1 more source

Development and prospective validation of postoperative pain prediction from preoperative EHR data using attention-based set embeddings

npj Digital Medicine, 2023
Preoperative knowledge of expected postoperative pain can help guide perioperative pain management and focus interventions on patients with the greatest risk of acute pain.
Ran Liu, Rodrigo Gutiérrez, Rory V. Mather, Tom A. D. Stone, Laura A. Santa Cruz Mercado, Kishore Bharadwaj, Jasmine Johnson, Proloy Das, Gustavo Balanza, Ekenedilichukwu Uwanaka, Justin Sydloski, Andrew Chen, Mackenzie Hagood, Edward A. Bittner, Patrick L. Purdon   +14 more
doaj   +1 more source

Randomized, controlled trial comparing respiratory and analgesic effects of interscalene, anterior suprascapular, and posterior suprascapular nerve blocks for arthroscopic shoulder surgery [PDF]

Korean Journal of Anesthesiology, 2020
Background Interscalene brachial plexus block (ISB) provides excellent analgesia for arthroscopic shoulder surgeries but is associated with adverse effects including hemidiaphragmatic paresis.
Yean Chin Lim, Zhao Kun Koo, Vivian. W. Ho, See Seong Chang, Shivani Manohara, Qian Jun Tong   +5 more
doaj   +1 more source

History of anesthesia usage in dentistry [PDF]

Stomatološki glasnik Srbije, 2005
Since prehistoric times, man has sought ways to lessen pain. With varying degrees of success he has utilized: opium, nerve compresses, cold, hypnosis, etc.
Koković Vladimir
doaj   +1 more source