Results 41 to 50 of about 6,840,055 (366)

In-hospital mortality does not increase in patients aged over 85 years after hip fracture surgery. A retrospective observational study in a Japanese tertiary hospital

JA Clinical Reports, 2018
Introduction Hip fracture is a common and serious orthopedic injury among the geriatric population, necessitating surgical treatment. We tested whether age is a significant risk factor for in-hospital mortality after surgery in this retrospective cohort ...
Yoshihisa Fujita, Kumi Shimada, Tomohiko Sato, Masahiko Akatsu, Koichi Nishikawa, Atsuko Kanno, Toshitake Aizawa   +6 more
doaj   +1 more source

Early childhood general anesthesia exposure associated with later developmental delay: A national population-based cohort study

PLoS ONE, 2020
Exposure to general anesthesia has been reported to induce neurotoxicity, impair learning, memory, attention, motor functions, as well as affect behavior in adult rodents and nonhuman primates.
Yu-Pin Feng, Tsorng-Shyang Yang, Chi-Hsiang Chung, W. Chien, Chih-Shung Wong   +4 more
semanticscholar   +1 more source

A lung rescue team improves survival in obesity with acute respiratory distress syndrome

Critical Care, 2020
Background Limited data exist regarding ventilation in patients with class III obesity [body mass index (BMI) > 40 kg/m2] and acute respiratory distress syndrome (ARDS). The aim of the present study was to determine whether an individualized titration of
Gaetano Florio, Matteo Ferrari, Edward A. Bittner, Roberta De Santis Santiago, Massimiliano Pirrone, Jacopo Fumagalli, Maddalena Teggia Droghi, Cristina Mietto, Riccardo Pinciroli, Sheri Berg, Aranya Bagchi, Kenneth Shelton, Alexander Kuo, Yvonne Lai, Abraham Sonny, Peggy Lai, Kathryn Hibbert, Jean Kwo, Richard M. Pino, Jeanine Wiener-Kronish, Marcelo B. P. Amato, Pankaj Arora, Robert M. Kacmarek, Lorenzo Berra, For the investigators of the lung rescue team   +24 more
doaj   +1 more source

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice

Journal of Neuroinflammation, 2019
Background It is widely accepted that mitochondria have a direct impact on neuronal function and survival. Oxidative stress caused by mitochondrial abnormalities play an important role in the pathophysiology of lipopolysaccharide (LPS)-induced memory ...
Weixing Zhao, Zhipeng Xu, Jiangbei Cao, Qiang Fu, Yishuang Wu, Xiaoying Zhang, Yue Long, Xuan Zhang, Yitian Yang, Yunfeng Li, Weidong Mi   +10 more
doaj   +1 more source

Preoperative anemia and total hospitalization time are the independent factors of preoperative deep venous thromboembolism in Chinese elderly undergoing hip surgery

BMC Anesthesiology, 2020
Background This study was designed to explore the prevalence and risk factors of preoperative deep venous thromboembolism (DVT) in Chinese elderly with hip fracture.
Long Feng, Longhe Xu, Weixiu Yuan, Zhipeng Xu, Zeguo Feng, Hong Zhang   +5 more
doaj   +1 more source

Effect of transcutaneous electrical acupoint stimulation on the quality of postoperative recovery: a meta-analysis

BMC Anesthesiology
Background The purpose of the present study was to systematically delve into the efficacy and safety of transcutaneous electrical acupoint stimulation (TEAS) on the quality of recovery after general anesthesia.
Meng Zhang, Huanhuan Zhang, Pan Li, Jianli Li   +3 more
doaj   +1 more source

Serious Sequelae of General Anesthesia

Annals of Surgery, 1972
Benjamin F. Byrd, Rollin A. Daniel, PRAMOD VASUDEO   +2 more
openalex   +6 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Dexmedetomidine inhibits the lipopolysaccharide‐stimulated inflammatory response in microglia through the pathway involving TLR4 and NF‐κB

Kaohsiung Journal of Medical Sciences, 2019
To investigate the effects of dexmedetomidine (DEX) on lipopolysaccharide (LPS)‐induced neuroinflammation in BV2 microglia. BV2 microglial cells were treated with various concentrations of DEX (0, 1, 10, and 100 ng/mL) for 1 hour, and then incubated in ...
Xue‐Yue Zhou, Jing Liu, Zhi‐Peng Xu, Qiang Fu, Pei‐Qi Wang, Hong Zhang   +5 more
doaj   +1 more source

The Thermodynamics of General and Local Anesthesia [PDF]

Biophysical Journal, 2014
General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare, Sasse-Middelhoff, Henrike, Heimburg, Thomas   +2 more
openaire   +5 more sources