Results 71 to 80 of about 1,527,976 (335)

Does statistical model perform at par with computationally expensive general circulation model for decadal prediction?

Environmental Research Letters, 2021
Decadal predictions have gained immense importance over the last decade because of their use in near-term adaption planning. Computationally expensive coupled model intercomparison project phase 5 general circulation models (GCMs) are initialized every 5
Rishi Sahastrabuddhe, Subimal Ghosh
doaj   +1 more source

Plasma microRNA Signature as Predictive Marker of Clinical Response to Therapy During Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite the availability of effective therapies for Multiple Sclerosis (MS), the unpredictable nature of disease progression and the variability in individual treatment outcomes call for reliable biomarkers. This pilot study aims to investigate the potential of plasma circulating microRNAs (miRNAs) as predictive biomarkers for ...
Fortunata Carbone, Alessandra Colamatteo, Teresa Micillo, Gianmarco Abbadessa, Silvia Garavelli, Clorinda Fusco, Claudia Russo, Francesco Perna, Federica Garziano, Claudia La Rocca, Maria Mottola, Giorgia Teresa Maniscalco, Simona Bonavita, Antonio Luca Spiezia, Alessia Castiello, Roberta Lanzillo, Vincenzo Brescia Morra, Claudio Procaccini, Paola de Candia, Giuseppe Matarese   +19 more
wiley   +1 more source

Bayesian calibration of the Thermosphere-Ionosphere Electrodynamics General Circulation Model (TIE-GCM) [PDF]

Geoscientific Model Development, 2009
In this paper, we demonstrate a procedure for calibrating a complex computer simulation model having uncertain inputs and internal parameters, with application to the NCAR Thermosphere-Ionosphere-Electrodynamics General Circulation Model (TIE-GCM).
S. Guillas, J. Rougier, A. Maute, A. D. Richmond, C. D. Linkletter   +4 more
doaj  

Analysis of the Longitudinal Behavior of Serum Levels of Soluble Flt1 and Placental Growth Factor in Pregnant Patients With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective This study analyzed longitudinal trajectories of soluble Flt1 (sFlt1) levels, placenta growth factor (PlGF) levels, and sFlt1:PlGF ratios in a cohort of pregnant patients with systemic lupus erythematosus (SLE). Methods Blood samples were collected (14–18, 24–26, 30–32, 34–36, and 38–40 weeks), stored at −80°C, and evaluated for serum levels ...
Nilson R. de Jesús, Guilherme R. de Jesús, Marcela I. Lacerda, Flávia C. dos Santos, Jeane de S Nogueira, Luiz Cristóvão Porto, Evandro S. F. Coutinho, Evandro M. Klumb   +7 more
wiley   +1 more source

Variability of the Tropical Atlantic Ocean Simulated by a General Circulation Model with Two Different Mixed-Layer Physics

, 1993
The embedment of a 1.5 turbulence closure model in an ocean general circulation model of the equatorial Atlantic is presented. The eddy viscosity and diffusivity involved in the vertical mixing are defined as the product of a characteristic turbulent ...
B. Blanke, P. Delecluse
semanticscholar   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Petascale atmospheric general circulation models [PDF]

Journal of Physics: Conference Series, 2007
The High-Order Method Modeling Environment (HOMME) is a framework to investigate using high-order element-based methods to build conservative and accurate atmospheric general circulation models. Currently, HOMME employs the discontinuous Galerkin and spectral element methods on a cubed-sphere tiled with quadrilateral elements to solve the primitive ...
Henry M. Tufo, Ramachandran D. Nair
openaire   +1 more source

Colchicine Concentrations and Relationship With Colchicine Efficacy and Adverse Events: Post Hoc Analysis of a Randomized Clinical Trial of Colchicine for Gout Flare Prophylaxis

Arthritis Care &Research, EarlyView.
Objective Our objective was to examine the relationship between colchicine plasma concentrations and clinical and demographic factors and to determine the relationship between colchicine concentrations and colchicine efficacy and colchicine‐specific adverse events.
Lisa K. Stamp, Anne Horne, Borislav Mihov, Jill Drake, Janine Haslett, Peter Chapman, Daniel F. B. Wright, Christopher Frampton, Nicola Dalbeth   +8 more
wiley   +1 more source

DYAMOND: the DYnamics of the Atmospheric general circulation Modeled On Non-hydrostatic Domains

Progress in Earth and Planetary Science, 2019
A review of the experimental protocol and motivation for DYAMOND, the first intercomparison project of global storm-resolving models, is presented. Nine models submitted simulation output for a 40-day (1 August–10 September 2016) intercomparison period ...
B. Stevens, M. Satoh, L. Auger, J. Biercamp, C. Bretherton, Xi Chen, P. Düben, F. Judt, M. Khairoutdinov, D. Klocke, C. Kodama, L. Kornblueh, Shian‐Jiann Lin, P. Neumann, William M. Putman, N. Röber, R. Shibuya, B. Vannière, P. Vidale, N. Wedi, Linjiong Zhou   +20 more
semanticscholar   +1 more source

On the limitations of general circulation climate models

Geophysical Research Letters, 1990
General Circulation Models (GCMs) by definition calculate large‐scale dynamical and thermodynamical processes and their associated feedbacks from first principles. This aspect of GCMs is widely believed to give them an advantage in simulating global scale climate changes as compared to simpler models which do not calculate the large‐scale processes ...
James S. Risbey, Peter Stone
openaire   +2 more sources