Results 91 to 100 of about 431,391 (303)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Elucidating the genetic potential of hybrids derived from elite maize (Zea mays L.) inbreds for economic traits under North-Western Himalayan condition

Electronic Journal of Plant Breeding
This study was conducted to evaluate the combining ability of newly acquired maize inbred lines over the environments. Twenty-eight crosses developed by crossing eight elite inbreds in a half-diallel mating design were evaluated during kharif, 2019 for ...
Gaurav Sharma*, Uttam Chandel, Sawan Kumar, Satish Kumar Guleria and Nimit Kumar
doaj   +1 more source

Assessment of gene action and combining ability for fibre and yield contributing trais in interspecific and intraspecific hybrids of cotton

Czech Journal of Genetics and Plant Breeding, 2018
Combining ability analysis was performed in order to identify high-yielding genotypes and hybrids. Six lines were crossed with three testers using a line × tester mating design. General combining ability (GCA) of parents, specific combining ability (SCA)
Sana MUNIR, Muhammad Kamran QURESHI, Ahmad Naeem SHAHZAD, Hamid MANZOOR, Muhammad Ahmad SHAHZAD, Kashif ASLAM, Habib-Ur-Rehman ATHAR   +6 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Improving forecast accuracy by combining recursive and rolling forecasts [PDF]

This paper presents analytical, Monte Carlo, and empirical evidence on the effectiveness of combining recursive and rolling forecasts when linear predictive models are subject to structural change. We first provide a characterization of the bias-variance
Todd E. Clark, Michael W. McCracken
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Genetic evaluation of inbred plants based on BLUP of breeding value and general combining ability

, 2011
The testcross method is considered efficient for identifying inbred families with superior general combining ability. The objective of the present study was to assess the relative importance of the performance per se and in crossing in the selection of
José Marcelo Soriano Viana, Vinícius Ribeiro Faria, Marcos Deon Vilela de Resende, Ramon Vinícius de Almeida, Fabyano Fonseca e Silva   +4 more
core   +1 more source

Combining ability of indonesian tropical maize in two different seasons

, 2021
Testing an inbred cross for hybrid development requires a proper test cross method. The diallel is one crossing method to find out the magnitude of inbred combining ability, both general general (GCA) and specific combining ability (SCA) and specific ...
Suyadi, -
core   +1 more source

Adaptation of Diverse Maize Germplasm to Spring Season Conditions in Northeast China

Agronomy
Northeast China (NEC) is a major spring maize (Zea mays L.) growing belt, and the outputs substantially influence national grain production. However, the maize grain yield per unit area has little changes in recent years, partially due to the lack of ...
Yi Li, Zhiyuan Yang, Yong Shao, Zhenguo Jin, Li Gao, Yang Yu, Fengyi Zhang, Yuxing Zhang, Yuantao Nan, Mingshun Li, Degui Zhang, Zhuanfang Hao, Jianfeng Weng, Xinhai Li, Hongjun Yong   +14 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source