Results 81 to 90 of about 431,391 (303)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The utility of covariance of combining ability in plant breeding
, 1976 The definition of covariances of half- and full sibs, and hence that of variances of general and specific combining ability with regard to a quantitative character, is extended to take into account the respective covariances between a pair of characters.
Arunachalam , V.
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMBINING ABILITY IN F2 HYBRIDS PEAS (Pisum sativum L.)
, 2018 Used in this study Four varieties of Peas (Pisum sativum L.) viz, (1- Carina, 2- English, 3- Green Feast and 4- Little Marvel ) were Full diallel crossing carried out according to (Griffing 1956) first method (Model I) to produce F2 hybrids, of twelve ...
Shamil AL-Hamdany
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Genetic parameters of heritability and combining ability.
, 2014 VG: variance of general combining ability (GCA); VS: variance of specific combining ability (SCA); Vgf: contribution ratio of the female GCA variance to the total variance; Vgm: contribution ratio of the male GCA variance to the total variance; Vgfm ...
Yongming Zhou (429711) +2 more
core +1 more source
Diallel analysis and genetic differentiation of tropical and temperate maize inbred lines
Crop Breeding and Applied Biotechnology, 2018 This study aimed to evaluate hybrids obtained by the cross among temperate × tropical elite maize lines, and to determine the genetic diversity and population differentiation of these inbred lines.
Vania Portes Kulka +5 more
doaj
Diallel Analysis of Early Leaf Spot (Cercospora arachidicola Hori) Disease Resistance in Groundnut
Agronomy, 2019 Early leaf spot (ELS) is one of the major biotic constraints of groundnut production in West and Central Africa. A study using 6 × 6 F2 full diallel populations from six parents (NAMA, B188, PC79-79, QH243C, TS32-1, and CN94C) was conducted to ...
Adama Zongo +6 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source