Results 141 to 150 of about 2,473,923 (366)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Combining ability for yield and yield-associated traits in wheat (Triticum aestivum L.)

open access: yesElectronic Journal of Plant Breeding
The current breeding effort aims to develop new wheat genotypes with higher genetic potential, thereby contributing to food security. Ten wheat genotypes were crossed in a half-diallel mating design.
Afsar Ahmad1 and Rajesh Kumar Gupta2
doaj   +1 more source

Heterosis in maize single crosses derived from a yellow Tuxpeño variety in Brazil. [PDF]

open access: yes, 2018
Most maize (Zea mays L.) crosses in Tropical regions use the heterotic pattern of Tupeno dent and Caribbean flint. Corsses between related lines are not used for commercial production.
BARBOSA, D. M.   +3 more
core  

Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

Assessment of combining ability for grain yield of self-pollinated S5 maize (Zea mays L.) families of mixed germplasm

open access: yesPlant Varieties Studying and Protection, 2016
Purpose. Assessment and selection of self-pollinated S5 maize (Zea mays L.) families with high combining ability and wide adaptive capacity obtained on the basis of specially produced hybrids by crossing elite lines of various genetic plasms with the ...
О. Л. Гайдаш
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Combining Ability for Grain Yield and Popping Expansion in Popcorn (Zea mays everta) Hybrids

open access: yesTurkish Journal of Agriculture: Food Science and Technology
The poor yield and popping quality underscore the need for indigenous germplasm improvement. This study aimed to find parents with high general combining ability (GCA) and specific combining ability (SCA) for yield and popping traits.
Oloruntoba O. Olakojo   +3 more
doaj   +1 more source

Combining abilities and heterotic groups in Pisum sativum L. [PDF]

open access: yes, 2013
The objective of this research was to investigate the use of heterosis and estimates of the general combining ability (GCA) and specific combining ability (SCA) for yield and the yield-related traits for identifying suitable parents and forming heterotic
Cointry Peix, Enrique Luis   +4 more
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

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