Results 71 to 80 of about 7,046,045 (313)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Numeracy, 2016 In this paper, we describe the process at Michigan State University whereby we have created two courses, Math 101 and 102, designed to foster numeracy and alleviate mathematics anxiety. The courses--which are not sequential--provide a means of satisfying
Samuel L. Tunstall +6 more
doaj +1 more source
Chippenham College (FEFC inspection report; 27/95 and 20/98) [PDF]
, 1998 Comprises two Further Education Funding Council (FEFC) inspection reports for the periods 1994-95 (27/95), and 1997-98 (20/98). The FEFC has a legal duty to make sure further education in England is properly assessed.
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
مسائل کاربردی تعلیم و تربیت اسلامی, 2019 The Quran is the most complete and best life plan for people who have always sought to learn, and education and it has been most valuable act for them. Hence, in the general goals of educational system, special attention has been paid to the necessity ...
Leila Khosravi Morad +3 more
doaj
A Confucian Perspective on Tertiary Education for the Common Good [PDF]
, 2018 Confucian education is best captured by the programme described in the Great Learning. Education is presented first as the process of self-cultivation for the sake of developing virtuous character. Self-cultivation then allows for virtue to be cultivated
Eh, Edmond
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi +5 more
wiley +1 more source
Language Attitudes of Parents with Russian L1 in Tartu: Transition to Estonian-Medium Education
LanguagesIn 2023, the authors conducted a qualitative study in five bilingual educational institutions (two general education schools and three kindergartens) in Tartu, Estonia, undergoing a transition to Estonian-medium education. The empirical material for this
Birute Klaas-Lang +2 more
doaj +1 more source
Challenges To The Implementation Of Institutional Reform In The Lithuanian General Education System
Baltic Journal of Law & Politics, 2015 The educational system of Lithuania has undergone transformation conditioned by the radical change of the political situation in the region after the restoration of independence on March 11, 1990.
Pranevičienė Birutė +1 more
doaj +1 more source