Results 51 to 60 of about 1,880,777 (265)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Literacy education in China within an Inclusive Education context

open access: yesPer Linguam : A Journal of Language Learning, 2016
To realise educational equality and construct a harmonious society, many scholars have valued and promoted inclusive education in China. More and more scholarly works are being devoted to this topic, forming three main types of studies: basic theories ...
Zhou, Quan , Yang, Jiong
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

MODEL METHODS OF UPBRINGING OF PUPILS IN THE LEARNING PROCESS OF BIOLOGY AND ECOLOGY

open access: yesВестник Северо-Кавказского федерального университета, 2022
One of the priorities of school education is the upbringing ofpupils. Educational subject's biology and ecology solve this problem by their own means. The problem of upbringing of pupils faced the methodology of teaching biology and ecology at all times.
A. Semenov
doaj  

A formation of secular school education in the Tatar settlements of Mordovia (1910s – early 1940s)

open access: yesИзвестия высших учебных заведений. Поволжский регион: Гуманитарные науки, 2022
Background. Researches are interested in the educational policy of the USSR so far, especially in the context of a multinational state. In this article, the formation of a secular school is shown by the example of the Tatars of Mordovia, whose history ...
A.N. Zankina
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Quantitative Literacy at Michigan State University, 3: Designing General Education Mathematics Courses

open access: yesNumeracy, 2016
In this paper, we describe the process at Michigan State University whereby we have created two courses, Math 101 and 102, designed to foster numeracy and alleviate mathematics anxiety. The courses--which are not sequential--provide a means of satisfying
Samuel L. Tunstall   +6 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Conceptual Foundations for Organizing Special Learning Conditions for Schoolchildren with Musculoskeletal Impairments

open access: yesИнтеграция образования
Introduction. The transformation of the school education system for children with musculoskeletal impairments, driven by changes in public life and legislation, is a response to the social demand for the quality and accessibility of education for ...
Alla Ya. Abkovich, Irina Yu. Levchenko
doaj   +1 more source

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