Results 81 to 90 of about 7,269,794 (356)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The Education (Penalty Notices) (England) (Amendment) Regulations 2013 [PDF]
, 2013 Enabling power: Education Act 1996, ss. 444B (1) (2) (4), 569 and Education and Inspections Act 2006, ss. 106 (1) (2) (4), 181. Issued: 04.04.2013. Made: 26.03.2012. Laid: 04.04.2013. Coming into force: 01.09.2013. Effect: S.I.
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
MODEL METHODS OF UPBRINGING OF PUPILS IN THE LEARNING PROCESS OF BIOLOGY AND ECOLOGY
Вестник Северо-Кавказского федерального университета, 2022 One of the priorities of school education is the upbringing ofpupils. Educational subject's biology and ecology solve this problem by their own means. The problem of upbringing of pupils faced the methodology of teaching biology and ecology at all times.
A. Semenov
doaj
A formation of secular school education in the Tatar settlements of Mordovia (1910s – early 1940s)
Известия высших учебных заведений. Поволжский регион: Гуманитарные науки, 2022 Background. Researches are interested in the educational policy of the USSR so far, especially in the context of a multinational state. In this article, the formation of a secular school is shown by the example of the Tatars of Mordovia, whose history ...
A.N. Zankina
doaj +1 more source
Can We Really Prevent Suicide? [PDF]
, 2012 Every year, suicide is among the top 20 leading causes of death globally for all ages. Unfortunately, suicide is difficult to prevent, in large part because the prevalence of risk factors is high among the general population. In this review, clinical and
A Fagiolini +111 more
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Numeracy, 2016 In this paper, we describe the process at Michigan State University whereby we have created two courses, Math 101 and 102, designed to foster numeracy and alleviate mathematics anxiety. The courses--which are not sequential--provide a means of satisfying
Samuel L. Tunstall +6 more
doaj +1 more source
General Education, Vocational Education, and Labor-Market Outcomes over the Life-Cycle [PDF]
Policy debates about the balance of vocational and general education programs focus on the school-to-work transition. But with rapid technological change, gains in youth employment from vocational education may be offset by less adaptability and thus ...
Eric A. Hanushek +2 more
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Chippenham College (FEFC inspection report; 27/95 and 20/98) [PDF]
, 1998 Comprises two Further Education Funding Council (FEFC) inspection reports for the periods 1994-95 (27/95), and 1997-98 (20/98). The FEFC has a legal duty to make sure further education in England is properly assessed.
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