Results 51 to 60 of about 1,475,466 (268)

Calculate large-scale indicators via variation of small-scale data (CLIVS): A general known-to-unknown approach and its application

Journal of Rock Mechanics and Geotechnical Engineering
Engineering problems often involve large spatial scales and long-term lifespans. This makes it exceptionally difficult to measure engineering parameters and predict disasters such as slope instability or tunnel collapses.
Shigui Du
doaj   +1 more source

ECNet is an evolutionary context-integrated deep learning framework for protein engineering

Nature Communications, 2021
Protein engineering is an active area of research in which machine learning has proven quite powerful. Here, the authors present a deep learning method that integrates both general and protein-specific sequence representations to improve the engineering ...
Yunan Luo, Guangde Jiang, Tianhao Yu, Yang Liu, Lam Vo, Hantian Ding, Yufeng Su, Wesley Wei Qian, Huimin Zhao, Jian Peng   +9 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Surface entropy-engineering: Towards general synthesis of high entropy subnano-oxides

Nano Research
High entropy oxides (HEOs), composed of at least five nearly equimolar principal atoms occupying a similar sublattice, demonstrate promising catalytic potential but limited activity.
Siyang Nie, Qingda Liu, Liang Wu, Xun Wang   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

What Engineering Sophomores Know and Would Like to Know About Engineering Information Sources and Access.

Issues in Science and Technology Librarianship, 2009
This exploratory study reports on what engineering undergraduate students know and would like to learn about engineering information sources and access.
Zorana Ercegovac
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Evaluation of compatibility and differences of liquefaction prediction methods based on different in-situ tests

Yantu gongcheng xuebao
Three liquefaction prediction methods, namely in-situ standard penetration test (SPT), shear wave velocity test (Vs), and cone penetration test (CPT), are gradually being incorporated into the codes.
YUAN Jinyuan , LI Weijia , WANG Tao , WANG Yingying
doaj   +1 more source

Photogrammetry Laser Scanning and Reverse Engineering Conrad’s Jewel [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Laser scanning, photogrammetry, and other technical tools are staples for cultural heritage documentation and reverse engineering projects. However, manufacturers and even researchers often conflate the data capture process with reverse engineering ...
A. Weigert, S. Kurcenli Koyunlu, M. Santana Quintero, S. Fai   +3 more
doaj   +1 more source