Results 71 to 80 of about 1,475,466 (268)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Exploring Students’ Experiences with Mindfulness Meditations in a First-Year General Engineering Course

Education Sciences
With growing mental health concerns among college students, they need to effectively develop skills to alleviate stress amidst the demands of university life.
Larkin Martini, Mark Vincent Huerta, Jazmin Jurkiewicz, Brian Chan, Diana Bairaktarova   +4 more
doaj   +1 more source

Mathematical modeling technique

AIP Advances, 2019
In this paper, a general modeling principle is introduced that was found useful for modeling complex physical systems for engineering applications.
R. T. Longo
doaj   +1 more source

Early Childhood Science and Engineering: Engaging Platforms for Fostering Domain-General Learning Skills

Education Sciences, 2018
Early childhood science and engineering education offer a prime context to foster approaches-to-learning (ATL) and executive functioning (EF) by eliciting children’s natural curiosity about the world, providing a unique opportunity to engage ...
Andres S. Bustamante, Daryl B. Greenfield, Irena Nayfeld   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Lindbladian reverse engineering for general non-equilibrium steady states: A scalable null-space approach

SciPost Physics
The study of open system dynamics is of paramount importance both from its fundamental aspects as well as from its potential applications in quantum technologies.
Leonardo da Silva Souza, Fernando Iemini
doaj   +1 more source

Multidisplinary Engineering, Project, and Production Management [PDF]

Journal of Engineering, Project, and Production Management, 2012
Journal of Engineering, Project, and Production Management (EPPM-Journal) reflect the journal’s multidisciplinary approach to management research and can be categorized as belonging to three general topics: Project Management, Engineering and Project ...
Chien-Ho Ko
doaj  

Abiotic Stresses: General Defenses of Land Plants and Chances for Engineering Multistress Tolerance

Frontiers in Plant Science, 2018
Abiotic stresses, such as low or high temperature, deficient or excessive water, high salinity, heavy metals, and ultraviolet radiation, are hostile to plant growth and development, leading to great crop yield penalty worldwide.
Mei He, Cheng-Qiang He, Nai-Zheng Ding
doaj   +1 more source

The General Mediation Engine

Proceedings of the AAAI Conference on Artificial Intelligence and Interactive Digital Entertainment, 2014
The General Mediation Engine is an architecture for producing game experiences with world mechanics drawn from a planning domain and problem. The system models possible player actions, state updates, and system responses in a graph representation derived from planner input.
Justus Robertson, R. Young
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source