Results 41 to 50 of about 2,998 (256)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Nonlinear Analysis, 2022 General fractional calculus is popular recently. Fractional uncertain differential equations (FUDEs) with general memory effects are proposed in this paper.
Cheng Luo, Guo-Cheng Wu, Lan-Lan Huang
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An operational calculus formulation of fractional calculus with general analytic kernels
Electronic Research Archive, 2022 <abstract><p>Fractional calculus with analytic kernels provides a general setting of integral and derivative operators that can be connected to Riemann–Liouville fractional calculus via convergent infinite series. We interpret these operators from an algebraic viewpoint, using Mikusiński's operational calculus, and utilise this algebraic ...
Rani, Noosheza, Fernandez, Arran
openaire +4 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Non-Additivity and Additivity in General Fractional Calculus and Its Physical Interpretations
Fractal and FractionalIn this work, some properties of the general convolutional operators of general fractional calculus (GFC), which satisfy analogues of the fundamental theorems of calculus, are described. Two types of general fractional (GF) operators on a finite interval
Vasily E. Tarasov
doaj +1 more source
The Generalized Fractional Calculus of Variations
, 2014 This is a preprint of a paper whose final and definite form will appear in Southeast Asian Bulletin of Mathematics (2014)
Odzijewicz, Tatiana +1 more
openaire +3 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Katugampola Fractional Calculus With Generalized k−Wright Function
European Journal of Mathematical Analysis, 2021 In this article, we present some properties of the Katugampola fractional integrals and derivatives. Also, we study the fractional calculus properties involving Katugampola Fractional integrals and derivatives of generalized k−Wright function nΦkm(z).
Ahmad Y. A. Salamooni, D. D. Pawar
openaire +4 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source