Results 51 to 60 of about 2,998 (256)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Can Fractional Calculus be Generalized: Problems and Efforts
European Journal of Pure and Applied Mathematics, 2018 Fractional order calculus always includes integer-order too. The question that crops up is: Can it be a widely accepted generalized version of classical calculus? We attempt to highlight the current problems that come in the way to define the fractional calculus that will be universally accepted as a perfect generalized version of integer-order ...
Sen, Syamal K. +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Regression Coefficient Derivation via Fractional Calculus Framework
Journal of Mathematics, 2022 This study focuses on deriving coefficients of a simple linear regression model and a quadratic regression model using fractional calculus. The work has proven that there is a smooth connection between fractional operators and classical operators ...
Muath Awadalla +3 more
doaj +1 more source
An Intuitive Introduction to Fractional and Rough Volatilities
Mathematics, 2021 Here, we review some results of fractional volatility models, where the volatility is driven by fractional Brownian motion (fBm). In these models, the future average volatility is not a process adapted to the underlying filtration, and fBm is not a ...
Elisa Alòs, Jorge A. León
doaj +1 more source
Fractional Calculus of Variations in Terms of a Generalized Fractional Integral with Applications to Physics [PDF]
Abstract and Applied Analysis, 2012 We study fractional variational problems in terms of a generalized fractional integral with Lagrangians depending on classical derivatives, generalized fractional integrals and derivatives. We obtain necessary optimality conditions for the basic and isoperimetric problems, as well as natural boundary conditions for free‐boundary value problems.
Odzijewicz, Tatiana +2 more
openaire +5 more sources
Operational Calculus for the General Fractional Derivative and Its Applications [PDF]
Fractional Calculus and Applied Analysis, 2021 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source