Results 61 to 70 of about 2,998 (256)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Generating the generalized distributions by using fractional calculus

Journal of Hyperstructures, 2016
In this paper, we generalized some statistical distribu- tions by using fractional calculus. The domain of parameter space for these distributions was expanded and their PDFs also presented as a product of fractional derivation of Dirac delta function of shape parameter order.
Ganji, Masoud, Gharari, Fatemeh
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Generalized integral inequalities for fractional calculus

Cogent mathematics & statistics, 2018
In this paper, we present a variety of integral inequalities in Lp and Lp, r spaces for the integral operator involving generalized Mittag-Leffler function in its kernel, Hilfer fractional derivative, generalized Riemann-Liouville and Riemann- Liouville k-fractional integral operators.
Iqbal, Sajid, Pečarić, Josip, Samraiz, Muhammad   +2 more
openaire   +3 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Theoretical Analysis of Fractional Viscoelastic Flow in Circular Pipes: General Solutions

Applied Sciences, 2020
Fractional calculus is a relatively old yet emerging field of mathematics with the widest range of engineering and biomedical applications. Despite being an incredibly powerful tool, it, however, requires promotion in the engineering community.
Dmitry Gritsenko, Roberto Paoli
doaj   +1 more source

ON GENERALIZED THE CONFORMABLE FRACTIONAL CALCULUS

, 2019
In this paper, we generalize the conformable fractional derivative and integral and obtain several results such as the product rule, quotient rule, chain rule.
SARIKAYA, M. Z., BUDAK, H., USTA, H.
openaire   +5 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Operational Calculus for the 1st-Level General Fractional Derivatives and Its Applications

Mathematics
The 1st-level General Fractional Derivatives (GFDs) combine in one definition the GFDs of the Riemann–Liouville type and the regularized GFDs (or the GFDs of the Caputo type) that have been recently introduced and actively studied in the fractional ...
Maryam Alkandari, Yuri Luchko
doaj   +1 more source