The auto-inhibitory role of the EPAC hinge helix as mapped by NMR. [PDF]
PLoS ONE, 2012 The cyclic-AMP binding domain (CBD) is the central regulatory unit of exchange proteins activated by cAMP (EPAC). The CBD maintains EPAC in a state of auto-inhibition in the absence of the allosteric effector, cAMP.
Rajeevan Selvaratnam +3 more
doaj +1 more source
An Extended Winged Helix Domain in General Transcription Factor E/IIEα [PDF]
Journal of Biological Chemistry, 2003 Initiation of eukaryotic mRNA transcription requires melting of promoter DNA with the help of the general transcription factors TFIIE and TFIIH. Here we define a conserved and functionally essential N-terminal domain in TFE, the archaeal homolog of the large TFIIE subunit alpha.
Meinhart, A., Blobel, J., Cramer, P.
openaire +5 more sources
Synthesis and viscosity behavior of poly(γ-p-biphenylmethyl-L-glutamate) in benzene/dichloroacetic acid mixtures, a comparison with poly(γ-benzyl-L-glutamate) [PDF]
, 1974 The synthesis of poly(γ-p-biphenylmethyl-L-glutamate), PBPLG, (poly{L-imino-1-[2-(4-biphenylylmethoxycarbonyl)ethyl]-2-oxoethylene}), (1d) is described. The viscosity behavior of this polymer in benzene/dichloroacetic acid mixtures (c=0,2.10 -3 - 1,4.10 -
Bantjes, Adriaan +4 more
core +3 more sources
Structural basis of antifreeze activity of a bacterial multi-domain antifreeze protein. [PDF]
PLoS ONE, 2017 Antifreeze proteins (AFPs) enhance the survival of organisms inhabiting cold environments by affecting the formation and/or structure of ice. We report the crystal structure of the first multi-domain AFP that has been characterized.
Chen Wang +4 more
doaj +1 more source
Some new types of associated curves in Euclidean 3-space
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2018 In this paper, we introduce the concept of D-direction curve and C- direction curve of a given curve using the alternative frame –N,C,W} in Euclidean 3-space.
Özdoğan Sibel +3 more
doaj +1 more source
Double stranded antiferromagnetic helix as an efficient spin filter
Results in Physics, 2023 We report a large degree of spin filtration in a double stranded (ds) antiferromagnetic helix (AFH) system. Generally spin channel separation is not possible when a magnetic system possesses a vanishing net magnetization.
Debjani Das Gupta +4 more
doaj +1 more source
Nanomaterials, 2021 The chirality quantification is of great importance in structural biology, where the differences in proteins twisting can provide essentially different physiological effects.
Vladimir Bystrov +8 more
doaj +1 more source
Exploring Flexibility of Progesterone Receptor Ligand Binding Domain Using Molecular Dynamics. [PDF]
PLoS ONE, 2016 Progesterone receptor (PR), a member of nuclear receptor (NR) superfamily, plays a vital role for female reproductive tissue development, differentiation and maintenance.
Liangzhen Zheng +2 more
doaj +1 more source
Evidence-Based Structural Model of the Staphylococcal Repressor Protein: Separation of Functions into Different Domains. [PDF]
PLoS ONE, 2015 Horizontal transfer of mobile genetic elements within Staphylococci is of high biomedical significance as such elements are frequently responsible for virulence and toxic effects.
Kinga Nyíri +4 more
doaj +1 more source
Radial Spin Helix in Two-Dimensional Electron Systems with Rashba Spin-Orbit Coupling
, 2010 We suggest a long-lived spin polarization structure, a radial spin helix, and study its relaxation dynamics. For this purpose, starting with a simple and physically clear consideration of spin transport, we derive a system of equations for spin ...
F. Reif +5 more
core +1 more source