Results 41 to 50 of about 169,060 (266)

A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. [PDF]

PLoS Computational Biology, 2008
Cyclic nucleotides (cAMP and cGMP) regulate multiple intracellular processes and are thus of a great general interest for molecular and structural biologists.
Alexandr P Kornev, Susan S Taylor, Lynn F Ten Eyck   +2 more
doaj   +1 more source

Generalized phantom helix states in quantum spin graphs

, 2023
In general, the summation of a set of sub-Hamiltonians cannot share a common eigenstate of each one, only if it is an unentangled product state, such as a phantom helix state in quantum spin system. Here we present a method, referred to as the building block method (BBM), for constructing possible spin-1/2 XXZ Heisenberg lattice systems possessing ...
Zhang, C. H., Shi, Y. B., Song, Z.
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Structural and Biochemical Insights into the Peptidoglycan Hydrolase Domain of FlgJ from Salmonella typhimurium. [PDF]

PLoS ONE, 2016
FlgJ is a glycoside hydrolase (GH) enzyme belonging to the Carbohydrate Active enZyme (CAZy) family GH73. It facilitates passage of the bacterial flagellum through the peptidoglycan (PG) layer by cleaving the β-1,4 glycosidic bond between N ...
Patryk Zaloba, Ben A Bailey-Elkin, Miriam Derksen, Brian L Mark   +3 more
doaj   +1 more source

Insights into electron wind force by a helical dislocation reconfiguration

iScience, 2023
Summary: Many efforts for decades have been made to explore electron wind force, produced by electric current itself under electropulsing treatment. However, the clear evidence of this force is hard to separate from Joule heating. Here we study a helical
Chang Zhou, Lihua Zhan, Chunhui Liu, Minghui Huang   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Voltage-Dependent Deactivation of the KvAP Channel Involves the Breakage of Its S4 Helix

Frontiers in Molecular Biosciences, 2020
Voltage-gated potassium channels (Kv) allow ion permeation upon changes of the membrane electrostatic potential (Vm). Each subunit of these tetrameric channels is composed of six transmembrane helices, of which the anti-parallel helix bundle S1-S4 ...
Olivier Bignucolo, Olivier Bignucolo, Simon Bernèche, Simon Bernèche   +3 more
doaj   +1 more source

bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana

iScience, 2022
Summary: Root, shoot, and lateral meristems are the main regions of cell proliferation in plants. It has been proposed that meristems might have evolved dedicated transcriptional networks to balance cell proliferation. Here, we show that basic helix-loop-
Eliana Mor, Markéta Pernisová, Max Minne, Guillaume Cerutti, Dagmar Ripper, Jonah Nolf, Jennifer Andres, Laura Ragni, Matias D. Zurbriggen, Bert De Rybel, Teva Vernoux   +10 more
doaj   +1 more source

Attenuated function of a variant form of the helix‐loop‐helix protein, Id‐3, generated by an alternative splicing mechanism

FEBS Letters, 1996
The Id family of helix‐loop‐helix proteins function as negative regulators of DNA binding, basic helix‐loop‐helix proteins in the regulation of cell growth and differentiation. We report here on the identification of a 17 kDa variant of the 14 kDa Id‐3 protein termed Id‐3L (long version) which possesses a unique 60 amino acid carboxy‐terminus generated
Deed, Richard W., Jasiok, Michelle, Norton, John D.   +2 more
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source