Results 51 to 60 of about 4,300 (261)

On characterizations of g n-helices with Euler angles

Open Mathematics
Curvature and torsion, in their most general forms, are defined in terms of Euler angle-based parametrization via the Cartan matrix, which leads to the Serret-Frenet equations.
Altinok Mesut, Kula Levent
doaj   +1 more source

A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. [PDF]

PLoS Computational Biology, 2008
Cyclic nucleotides (cAMP and cGMP) regulate multiple intracellular processes and are thus of a great general interest for molecular and structural biologists.
Alexandr P Kornev, Susan S Taylor, Lynn F Ten Eyck   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Insights into electron wind force by a helical dislocation reconfiguration

iScience, 2023
Summary: Many efforts for decades have been made to explore electron wind force, produced by electric current itself under electropulsing treatment. However, the clear evidence of this force is hard to separate from Joule heating. Here we study a helical
Chang Zhou, Lihua Zhan, Chunhui Liu, Minghui Huang   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Voltage-Dependent Deactivation of the KvAP Channel Involves the Breakage of Its S4 Helix

Frontiers in Molecular Biosciences, 2020
Voltage-gated potassium channels (Kv) allow ion permeation upon changes of the membrane electrostatic potential (Vm). Each subunit of these tetrameric channels is composed of six transmembrane helices, of which the anti-parallel helix bundle S1-S4 ...
Olivier Bignucolo, Olivier Bignucolo, Simon Bernèche, Simon Bernèche   +3 more
doaj   +1 more source

Structural and Biochemical Insights into the Peptidoglycan Hydrolase Domain of FlgJ from Salmonella typhimurium. [PDF]

PLoS ONE, 2016
FlgJ is a glycoside hydrolase (GH) enzyme belonging to the Carbohydrate Active enZyme (CAZy) family GH73. It facilitates passage of the bacterial flagellum through the peptidoglycan (PG) layer by cleaving the β-1,4 glycosidic bond between N ...
Patryk Zaloba, Ben A Bailey-Elkin, Miriam Derksen, Brian L Mark   +3 more
doaj   +1 more source

Attenuated function of a variant form of the helix‐loop‐helix protein, Id‐3, generated by an alternative splicing mechanism

FEBS Letters, 1996
The Id family of helix‐loop‐helix proteins function as negative regulators of DNA binding, basic helix‐loop‐helix proteins in the regulation of cell growth and differentiation. We report here on the identification of a 17 kDa variant of the 14 kDa Id‐3 protein termed Id‐3L (long version) which possesses a unique 60 amino acid carboxy‐terminus generated
Deed, Richard W., Jasiok, Michelle, Norton, John D.   +2 more
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

III-harmonic Curves in SL2ℝ˜\widetilde {{\rm{S}}{{\rm{L}}_2}\mathbb{R}} Space

Annals of the West University of Timisoara: Mathematics and Computer Science
Some work has been done in the study of non-geodesic III-harmonic curves in some model spaces. In this paper, we study III-harmonic curves in SL2ℝ˜\widetilde {{\rm{S}}{{\rm{L}}_2}\mathbb{R}} space. We give necessary and su cient conditions for helices to
Senoussi Bendehiba
doaj   +1 more source