Results 51 to 60 of about 174,885 (266)
A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. [PDF]
PLoS Computational Biology, 2008 Cyclic nucleotides (cAMP and cGMP) regulate multiple intracellular processes and are thus of a great general interest for molecular and structural biologists.
Alexandr P Kornev +2 more
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Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Structural and Biochemical Insights into the Peptidoglycan Hydrolase Domain of FlgJ from Salmonella typhimurium. [PDF]
PLoS ONE, 2016 FlgJ is a glycoside hydrolase (GH) enzyme belonging to the Carbohydrate Active enZyme (CAZy) family GH73. It facilitates passage of the bacterial flagellum through the peptidoglycan (PG) layer by cleaving the β-1,4 glycosidic bond between N ...
Patryk Zaloba +3 more
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Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Acta Societatis Botanicorum Poloniae, 2015 The study material consisted of samples from 270 Picea excelsa and 54 Abies alba trees with variable type of wood grain. No correlation was found between the orientation of the fibrils and the type of grain.
W. Pyszyński, Z. Hejnowicz
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The Voltage-Dependent Deactivation of the KvAP Channel Involves the Breakage of Its S4 Helix
Frontiers in Molecular Biosciences, 2020 Voltage-gated potassium channels (Kv) allow ion permeation upon changes of the membrane electrostatic potential (Vm). Each subunit of these tetrameric channels is composed of six transmembrane helices, of which the anti-parallel helix bundle S1-S4 ...
Olivier Bignucolo +3 more
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New results for general helix in Euclidean 3-space
AIP Conference Proceedings, 2018 Finding parametric equation of a space curve is not easy task when its curvature functions are given. It is well known that this problem is known as fundamental theorem of a space curve. If the curvature functions are functions of arc-length, the solution of this problem is usually impossible.
openaire +2 more sources
Cyclical Surfaces Created by Helix on General Surface of Revolution [PDF]
sspjce, 2013 Abstract This paper describes the method for modelling of cyclical surfaces created by the helix on the general surface of revolution Φ. The axis of the cyclical surface Φ1 is the helix s created by screwing the point located on the surface Φ about the axis of this surface. The circle moves together with Frenet-Serret moving trihedron
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
General helices on a class of generalized cylinders
Open MathematicsWe study unit-speed general helices on a class of generalized cylinders in Euclidean 3-space whose base curve is planar and whose ruling direction is orthogonal to the base plane.
Mollaoğulları Ahmet
doaj +1 more source