Results 71 to 80 of about 4,300 (261)
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Frenet Curves and Successor Curves: Generic Parametrizations of the Helix and Slant Helix
, 2013 In classical curve theory, the geometry of a curve in three dimensions is essentially characterized by their invariants, curvature and torsion. When they are given, the problem of finding a corresponding curve is known as 'solving natural equations'. Explicit solutions are known only for a handful of curve classes, including notably the plane curves ...
openaire +2 more sources
Versatility of helix–loop–helix catalysts — cooperative HisH+–His sites that span both helices
, 1999 Peptides with 42 amino acid residues have been designed to fold into helix-loop-helix motifs that dimerize to form four-helix bundles and catalyze the hydrolysis of p-nitrophenyl esters.
Lars Baltzer +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao +6 more
wiley +1 more source
Spiro-DKPs as potential α-helix mimetics.
, 2015 (A) General structure of the target spiro-DKPs with numbering. (B) The side chains of Leu26, Trp23, and Phe19 in the p53 helix.(C) Spiro-DKPs. (D) Superimposition of an Ala-helix (black), with a low energy conformation of a spiro-DKP B (green).
Maria Quant (802419) +8 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source
On the quaternionic Mannheim curves of Aw(k)-type in Euclidean space E3
Kuwait Journal of Science, 2015 In this paper, we consider that the curvature conditions of Aw(k)-type (1≤ k ≤ 3) quaternioniccurves in Euclidean space E3 and investigates quaternionic Mannheim curves α:I →Q withk ≠ 0 and r ≠ 0 .
SEZAI KIZILTUĞ, YUSUF YAYLI
doaj
, 2011 A gender gap in entrepreneurship and innovation can be discerned across Europe – often portrayed as a statistical pattern showing differences in prevalence of entrepreneurial and innovative activities between the categories of men and women.
Lindberg, Malin +2 more
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie +8 more
wiley +1 more source
NON-NULL CURVES OF TZITZEICA TYPE IN MINKOWSKI 3-SPACE [PDF]
Romanian Journal of Mathematics and Computer Science, 2014 In this paper, we study non-null curves of Tzitzeica type in Minkowski 3-space E_1^3 . We find a simple link between Tzitzeica curves and Rectifying curves in E_1^3.
Muhittin Evren AYDIN, Mahmut ERGÜT
doaj