Results 81 to 90 of about 365,940 (292)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

On the quaternionic Mannheim curves of Aw(k)-type in Euclidean space E3

Kuwait Journal of Science, 2015
In this paper, we consider that the curvature conditions of Aw(k)-type (1≤ k ≤ 3) quaternioniccurves in Euclidean space E3 and investigates quaternionic Mannheim curves α:I →Q withk ≠ 0 and r ≠ 0 .
SEZAI KIZILTUĞ, YUSUF YAYLI
doaj  

Frenet Curves and Successor Curves: Generic Parametrizations of the Helix and Slant Helix

, 2013
In classical curve theory, the geometry of a curve in three dimensions is essentially characterized by their invariants, curvature and torsion. When they are given, the problem of finding a corresponding curve is known as 'solving natural equations'. Explicit solutions are known only for a handful of curve classes, including notably the plane curves ...
openaire   +2 more sources

Exactly Solvable Model for Helix-Coil-Sheet Transitions in Protein Systems

, 2011
In view of the important role helix-sheet transitions play in protein aggregation, we introduce a simple model to study secondary structural transitions of helix-coil-sheet systems using a Potts model starting with an effective Hamiltonian.
D. Poland, Jian-Min Yuan, John S. Schreck   +2 more
core   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Relations between a Dual Unit Vector and Frenet Vectors of a Dual Curve

Kuwait Journal of Science, 2016
In this paper, we generalize the notions of helix and slant helix in dual space in a more general case such as the dual angle between a fixed dual unit vector and Frenet vectors of a dual curve is not constant.
Burak Şahiner, Mehmet Önder
doaj  

NON-NULL CURVES OF TZITZEICA TYPE IN MINKOWSKI 3-SPACE [PDF]

Romanian Journal of Mathematics and Computer Science, 2014
In this paper, we study non-null curves of Tzitzeica type in Minkowski 3-space E_1^3 . We find a simple link between Tzitzeica curves and Rectifying curves in E_1^3.
Muhittin Evren AYDIN, Mahmut ERGÜT
doaj  

Evolution of complex RNA polymerases: the complete archaeal RNA polymerase structure.

PLoS Biology, 2009
The archaeal RNA polymerase (RNAP) shares structural similarities with eukaryotic RNAP II but requires a reduced subset of general transcription factors for promoter-dependent initiation.
Yakov Korkhin, Ulug M Unligil, Otis Littlefield, Pamlea J Nelson, David I Stuart, Paul B Sigler, Stephen D Bell, Nicola G A Abrescia   +7 more
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source