Results 61 to 70 of about 11,466,083 (284)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Applications of the integral transforms composition method to wave-type singular differential equations and index shift transmutations

Electronic Journal of Differential Equations, 2018
In this article we study applications of integral transforms composition method (ITCM) for obtaining transmutations via integral transforms. It is possible to derive wide range of transmutation operators by this method.
Ahmed Fitouhi, Iness Jebabli, Elina L. Shishkina, Sergei M. Sitnik   +3 more
doaj  

Some Connections between the Spherical and Parabolic Bases on the Cone Expressed in terms of the Macdonald Function

Abstract and Applied Analysis, 2014
Computing the matrix elements of the linear operator, which transforms the spherical basis of SO(3,1)-representation space into the hyperbolic basis, very recently, Shilin and Choi (2013) presented an integral formula involving the product of two ...
I. A. Shilin, Junesang Choi
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The application of fourier integral transforms in a general theory of diffraction

Archives of Acoustics, 2016
Integral transforms have frequently been used to solve different specific problems in diffraction. There has, however, been no application of this method to the fundamental equations of diffraction theory. The present author shows that a transition from
Roman WYRZYKOWSKI
doaj  

Integral transform approach to generalized Tricomi equations

Journal of Differential Equations, 2015
We present some integral transform that allows to obtain solutions of the generalized Tricomi equation from solutions of a simpler equation. We used in [13,14],[41]-[46] the particular version of this transform in order to investigate in a unified way several equations such as the linear and semilinear Tricomi equations, Gellerstedt equation, the wave ...
openaire   +2 more sources

Integral transforms for engineers

, 1999
Integral transform methods provide effective ways to solve a variety of problems arising in the engineering, optical, and physical sciences. Suitable as a self-study for practicing engineers and applied mathematicians and as a textbook in graduate-level ...
Andrews, Larry C., Shivamoggi, Bhimsen K.   +1 more
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Applications of Generalized Integral Transforms

, 2015
Проблематика. Статтю присвячено дослідженню узагальнених інтегральних перетворень, а саме узагальненого інтеграль­ного перетворення Лапласа, узагальненого інтегрального перетворення Стільтьєса.Мета дослідження. Дослідження застосувань нових узагальнень класичних інтегральних перетворень для розв’язання диференціальних, інтегральних рівнянь, обчислення ...
Virchenko, N. O., Chetvertak, M. O.
openaire   +4 more sources

Schrödinger-type identity to the existence and uniqueness of a solution to the stationary Schrödinger equation

Boundary Value Problems, 2019
In this article we study applications of the Schrödinger-type identity for obtaining transmutations via the fixed point index for nonlinear integral equations. It is possible to derive a wide range of transmutation operators by this method.
Delin Sun
doaj   +1 more source