Results 81 to 90 of about 14,270,971 (389)

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source

Internal Assessment of Isfahan General Medicine Curriculum Based on Basic standards of Ministry of Health and Medical Education: A Model for Evaluation and Analysis of Results [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2011
Introduction: Necessity for promotion of education quality in course of medicine forced the educational authorities including those of Isfahan school of Medicine to take actions towards promotion of education using an accreditation evaluation model in ...
Mostafa Dehghani Poudeh, Behzad Shams, vahid Ashourioun, Atosa Esmaeilee, Ali Asilian, Parveneh Nasri, Marzieh Hosseini   +6 more
doaj  

The use of a Swedish telephone medical advice service by the elderly – a population-based study

Scandinavian Journal of Primary Health Care, 2017
Objective: The present study aimed to describe contact made by the elderly to Sweden’s nationwide medical helpline, Healthcare Guide 1177 by Phone (HGP).
K. Dahlgren, M. J. Holzmann, A. C. Carlsson, P. Wändell, J. Hasselström, T. Ruge   +5 more
doaj   +1 more source

Aspects of general medicine [PDF]

, 2008
Horizons in Medicine is a series produced annually by the Royal College of Physicians. Volume 19 is based on their Advanced Medicine Conference held in 2007 and offers updates on a wide range of topics in clinical medicine.
Kumana, CR
core  

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Die Versorgungssituation von Patient:innen mit spastischer Bewegungsstörung in Deutschland: ein Vergleich (II)

Monitor Versorgungsforschung, 2022
Hintergrund: Unterschiedlichste Publikationen der jüngeren Vergangenheit beschäftigten sich mit der Versorgungsrealität von Patient:innen mit spastischen Bewegungsstörungen in Deutschland und offenbarten eine Versorgung, die nicht mit den aktualisierten ...
Lukas Völkel MSc, Prof. Dr. rer. pol. h.c. Herbert Rebscher, Prof. Dr. rer. soc. Dr. med. Reinhard P.T. Rychlik   +2 more
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Swedish Medical LLM Benchmark: development and evaluation of a framework for assessing large language models in the Swedish medical domain

Frontiers in Artificial Intelligence
IntroductionWe present the Swedish Medical LLM Benchmark (SMLB), an evaluation framework for assessing large language models (LLMs) in the Swedish medical domain.MethodThe SMLB addresses the lack of language-specific, clinically relevant benchmarks by ...
Birger Moëll, Fabian Farestam, Jonas Beskow   +2 more
doaj   +1 more source

The future of general medicine [PDF]

Clinical Medicine, 2014
It is a truth universally acknowledged that there is a problem with general medicine. Physicians have become increasingly specialised over the past 30 years or so, and specialist care has produced increasingly better outcomes for some patients. The patients left behind are looked after by general medicine, where demand is increasing, operational ...
openaire   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source