Results 71 to 80 of about 2,849,424 (255)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Intraoperative hypotension and postoperative pneumonia in patients after selective intracranial tumor resection: a retrospective cohort study [PDF]

PeerJ
Background Postoperative pneumonia is common and associated with increased postoperative mortality. Intraoperative hypotension is suggested to be associated with an increased risk of postoperative surgical infection.
Yuan Chang, Yanqiong Wang, Yinyan Zhou, Huamei Chen, Yuanhua Li, Ruhua Long, Jianlin Shao   +6 more
doaj   +2 more sources

Age and multimorbidities as poor prognostic factors for COVID-19 in hemodialysis: a Lebanese national study

BMC Nephrology, 2021
Background Hemodialysis patients with COVID-19 have been reported to be at higher risk for death than the general population. Several prognostic factors have been identified in the studies from Asian, European or American countries.
Mabel Aoun, Rabab Khalil, Walid Mahfoud, Haytham Fatfat, Line Bou Khalil, Rashad Alameddine, Nabil Afiouni, Issam Ibrahim, Mohamad Hassan, Haytham Zarzour, Ali Jebai, Nina Mourad Khalil, Luay Tawil, Zeina Mechref, Zuhair El Imad, Fadia Chamma, Ayman Khalil, Sandy Zeidan, Balsam El Ghoul, Georges Dahdah, Sarah Mouawad, Hiba Azar, Kamal Abou Chahine, Siba Kallab, Bashir Moawad, Ahmad Fawaz, Joseph Homsi, Carmen Tabaja, Maya Delbani, Rami Kallab, Hassan Hoballah, Wahib Haykal, Najat Fares, Walid Rahal, Wael Mroueh, Mohammed Youssef, Jamale Rizkallah, Ziad Sebaaly, Antoine Dfouni, Norma Ghosn, Nagi Nawfal, Walid Abou Jaoude, Nadine Bassil, Therese Maroun, Nabil Bassil, Chadia Beaini, Boutros Haddad, Elie Moubarak, Houssam Rabah, Amer Attieh, Serge Finianos, Dania Chelala   +51 more
doaj   +1 more source

A higher-dimensional homologically persistent skeleton [PDF]

, 2019
Real data is often given as a point cloud, i.e. a finite set of points with pairwise distances between them. An important problem is to detect the topological shape of data — for example, to approximate a point cloud by a low-dimensional non-linear ...
Kalisnik, Sara, Kurlin, Vitaliy, Lesnik, Davorin   +2 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Nonparametric survival analysis of epidemic data

, 2011
This paper develops nonparametric methods for the survival analysis of epidemic data based on contact intervals. The contact interval from person i to person j is the time between the onset of infectiousness in i and infectious contact from i to j, where
Aalen, Aalen, Altshuler, Becker, Becker, Carcione, Cauchemez, Cox, Dempster, Donnelly, Ferguson, Ferguson, Fine, France, Fraser, Kalbfleisch, Kaplan, Kenah, Kenah, Lee, Lipsitch, McBryde, Mills, Morgan, Müller, Nelson, Rampey, Rhodes, Roberts, Sinha, Sugimoto, Svensson, Van der Vaart, Wallinga, Wallinga, Watts, Wegman, White, Yang   +38 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Change-Point Testing and Estimation for Risk Measures in Time Series

, 2018
We investigate methods of change-point testing and confidence interval construction for nonparametric estimators of expected shortfall and related risk measures in weakly dependent time series.
Fan, Lin, Glynn, Peter W., Pelger, Markus   +2 more
core  

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source