Results 81 to 90 of about 2,849,424 (255)

Parametric methods outperformed non-parametric methods in comparisons of discrete numerical variables

BMC Medical Research Methodology, 2011
Background The number of events per individual is a widely reported variable in medical research papers. Such variables are the most common representation of the general variable type called discrete numerical.
Sandvik Leiv, Fagerland Morten W, Mowinckel Petter   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Using health facility-based serological surveillance to predict receptive areas at risk of malaria outbreaks in elimination areas

BMC Medicine, 2020
Background In order to improve malaria burden estimates in low transmission settings, more sensitive tools and efficient sampling strategies are required.
Henry Surendra, Supargiyono, Riris A. Ahmad, Rizqiani A. Kusumasari, Theodola B. Rahayujati, Siska Y. Damayanti, Kevin K. A. Tetteh, Chetan Chitnis, Gillian Stresman, Jackie Cook, Chris Drakeley   +10 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

TRANSPORT OF PATIENTS FOR PRIMARY PTCA FROM GENERAL HOSPITAL NOVO MESTO TO LJUBLJANA

Zdravniški Vestnik, 2003
Background. The treatment of acute coronary syndrom (ACS) with ST-segment elevation with primary percutaneous transluminal coronary angioplasty (PTCA) has been a routine method for treatment of these patients in KC Ljubljana since April 2000.
Renata Okrajšek, Rafael Kapš, Srečko Starič, Branka Ožek, Boštjan Gorjup, Branko Gregorič, Janez Toplišek, Iztok Gradecki   +7 more
doaj  

A Bayesian approach to the study of white dwarf binaries in LISA data: The application of a reversible jump Markov chain Monte Carlo method

, 2009
The Laser Interferometer Space Antenna (LISA) defines new demands on data analysis efforts in its all-sky gravitational wave survey, recording simultaneously thousands of galactic compact object binary foreground sources and tens to hundreds of ...
Stroeer, Alexander, Veitch, John
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Ensemble learning to predict short birth interval among reproductive-age women in Ethiopia: evidence from EDHS 2016–2019

BMC Pregnancy and Childbirth
Background A birth interval of less than 33 months was considered short, and in low- income countries like Ethiopia, a short birth interval is the primary cause of approximately 822 maternal deaths every day. Due to that this study aimed to predict short
Jenberu Mekurianew Kelkay, Deje Sendek Anteneh, Henok Dessie Wubneh, Abraham Dessie Gessesse, Gebeyehu Fassil Gebeyehu, Kalkidan Kassahun Aweke, Mikiyas Birhanu Ejigu, Mathias Amare Sendeku, Kirubel Adrissie Barkneh, Hasset Girma Demissie, Wubshet D. Negash, Birku Getie Mihret   +11 more
doaj   +1 more source