Results 151 to 160 of about 16,433,437 (314)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Editors’ choice: The four most valued articles published in the European Journal of General Practice in 2019

open access: yesEuropean Journal of General Practice, 2020
Jelle Stoffers   +1 more
doaj   +1 more source

Neutrophil Extracellular Traps and Intestinal Diseases: A Narrative Review

open access: yesGastroenterology Research and Practice
Neutrophil extracellular traps (NETs) are a network-like structure released by neutrophils into the extracellular space in response to various stimuli, with DNA as the main component, to which histones, granulins, cytoplasmic proteins, and other proteins
Zhe Wang   +3 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

The burden of illness in families of the mentally ill : a view from general practice / Ian Geoffrey Wilson. [PDF]

open access: yes, 2002
"25 June 2002"Bibliography: leaves 213-236.xiii, 258, [7] leaves : ill. ; 30 cm.This thesis examines the health of families, as seen in general practice, where a member of the family had counselling as the only treatment for a mental health problem, or a
Wilson, Ian Geoffrey
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Point-of-care testing and antibiotics prescribing in out-of-hours general practice: a register-based study in Denmark

open access: yesBMC Primary Care
Background Point-of-care testing may reduce diagnostic uncertainty in case of suspicion of bacterial infection, thereby contributing to prudent antibiotic prescribing.
Line Due Christensen   +6 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

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