Results 141 to 150 of about 16,433,437 (314)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Factors Influencing Team-Based Vaccination Collaboration in Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Survey of Primary Care Teams in Beijing, China

International Journal of COPD
Yifan Hou,1 Ping Zhao,2 Yuzhe Shi,1 Meng Ren,1 Jing Hai,1 Yang Zhao,1 Na Zhang,1 Zhou Wang,1 Yi Qian,1 Xu Yang11Department of General Practice, Donghuashi Community Health Service Center, Beijing, People’s Republic of China; 2Department of Administration,
Hou Y, Zhao P, Shi Y, Ren M, Hai J, Zhao Y, Zhang N, Wang Z, Qian Y, Yang X   +9 more
doaj  

Implementation and acceptability of the Caregiver Care Model in general practice: a mixed-method feasibility study

BMC Primary Care
Background Being a caregiver can be demanding. Therefore, we developed the Caregiver Care Model for general practice. The model consists of a mandatory dialogue questionnaire, which is used to identify support needs in caregivers, grief-facilitating ...
Mette Kjaergaard Nielsen, Marie Cecilie Vinther, Mai-Britt Guldin, Kaj Sparle Christensen, Anna Mygind   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Core values and best practice criteria for interprofessional teams in primary care: a qualitative interview study with general practitioners and other health professionals from Bavaria, Germany

BMC Primary Care
Background The German healthcare system is confronted with a shortage of general practitioners (GPs) due to demographic changes and an aging workforce.
Katharina Zeiser, Dominik Weissenburger, Michaela Trompke, Lisa Schumacher, Simon Schwill, Wolfgang Ritter, Marco Roos   +6 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Multifaceted support to improve clinical decision making in diabetes care: a randomized controlled trial in general practice.

, 2002
Item does not contain fulltextAIMS: To evaluate the effectiveness of a multifaceted intervention to improve the clinical decision making of general practitioners (GPs) for patients with diabetes. To identify practice characteristics which predict success.
Lobo, C.M., Hulscher, MEJL, C. M. Lobo, Grol, RPTM, Hulscher, M.E.J.L., Grol, R.P.T.M., Lobo, CM (Claudia), Braspenning, JCC, Akkermans, R.P., Braspenning, J.C.C., M. E. J. L. Hulscher, Akkermans, RP, R. P. Akkermans, J. C. Van Der Wouden, Wouden, Hans, J. C. C. Braspenning, Prins, A., Frijling, B.D., A. Prins, Frijling, BD, Wouden, J.C. van der, B. D. Frijling, R. P. T. M. Grol, Prins, A (Ad)   +23 more
core   +1 more source

Clinical Features of Long COVID Patients Coinfected With Mycoplasma pneumoniae

Canadian Journal of Infectious Diseases and Medical Microbiology
Conclusions: Our study showed that long COVID–M. pneumoniae coinfection was more commonly seen in females and patients with typical chest computed tomography (CT) images.
Xiaodan Zhu, Yanhua Li, Jinghua Wang, Weifei Gao   +3 more
doaj   +1 more source