Results 121 to 130 of about 16,433,437 (314)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The inter-observer reproducibility of Lasegue's sign in patients with low back pain in general practice

, 1996
Background. The spectrum of low back pain patients in general practice differs significantly from that in an orthopaedic clinic. The most frequent specific cause of low back pain is nerve-root irritation or compression caused by intervertebral protrusion,
Bouter, L.M., Koes, B.W., Deville, W.L.J.M., Van Den Hoogen, Hans J.M., Eijk, J.T.M. van, Koes, Bart W., Koes, Bart W.; id_orcid, Hoogen, H.J.M. van den, Bouter, Lex M., Devillé, Walter, Van Eijk, Jacques Th M.   +10 more
core  

A Narrative Review of the Correlation Between Comorbidity and Acute Exacerbation of COPD Patients

International Journal of COPD
Qingdie Zhao, Wen Shen, Yayue Zhang, Yue Chen, Zhenyan LiDepartment of General Practice, The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, People’s Republic of China*These authors contributed equally to ...
Zhao Q, Shen W, Zhang Y, Chen Y, Li Z
doaj  

Development of a PROM to measure patient-centredness in chronic care consultations in primary care

Health and Quality of Life Outcomes
Introduction Validated patient-reported outcome measures (PROMs) are crucial for assessing patients’ experiences in the healthcare system. Both clinically and theoretically, patient-centered consultations are essential in patient-care, and are often ...
Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group   +15 more
doaj   +1 more source

Questions for general practice

BMJ, 2003
Tudor Hart describes the real stuff of primary medical care as the steady unglamorous slog of anticipatory care, where the exciting things have been events that have not happened.1 When acute events do occur, as in this case, the electronic responses from Bossano and Trivanovic rightly highlight the difficulties in diagnosing chest pain in the ...
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

General practice activity in Australia 2015–16 [PDF]

, 2016
This report is the 40th and penultimate book in the General practice series from the Bettering the Evaluation of Care and Health (BEACH) program.
Bayram, Clare, Britt, Helena, Miller, Graeme C, Pollack, Allan J, Henderson, Joan, Gordon, Julie, Charles, Janice, Wong, Carmen, Valenti, Lisa, Pan, Ying, Harrison, Christopher   +10 more
core  

Inhaled Therapy Adherence in COPD:A COM-B-Based Narrative Review of Determinants and Intervention Strategies

International Journal of COPD
Yayue Zhang, Wen Shen, Qingdie Zhao, Zhenyan Li, Yue ChenDepartment of General Practice, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China*These authors contributed equally to this ...
Zhang Y, Shen W, Zhao Q, Li Z, Chen Y
doaj  

Prevalence and risk factors of airflow obstruction in Southwest China: baseline findings from a multi-center population-based cohort study

BMC Pulmonary Medicine
Background Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder primarily characterized by persistent airflow obstruction.
Yao Lv, Xiaolong Tang, Shanye Yi, Yu Jia, Bojiang Chen, Jun Shao, Jieling Li, Yi Yao, Jing Xiong, Miaomiao Wu, Wenjun Fu, Jingxin Ma, Rui Zhang, Weimin Li, Yi Lei   +14 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source