Results 101 to 110 of about 8,173,281 (311)

Interpretable Machine Learning Model for Predicting 1-Year Unplanned Readmissions in Ischemic Stroke Patients with Diabetes: A Synergistic View of Inflammation and Metabolism

Clinical Interventions in Aging
Yue Hu,1,* Yunhong Zhang,2,* Peichong Lin,3,4,* Xinye Hu,5 Yiping Zhu,6 Peiling Yan,7 Fan Fei,8 Qiuyan Wang,9 Xuelin Yao,10 Jingjing Ren1 1Department of General Practice, the First Affiliated Hospital, Zhejiang University School ...
Hu Y, Zhang Y, Lin P, Hu X, Zhu Y, Yan P, Fei F, Wang Q, Yao X, Ren J   +9 more
doaj  

Development of a PROM to measure patient-centredness in chronic care consultations in primary care

Health and Quality of Life Outcomes
Introduction Validated patient-reported outcome measures (PROMs) are crucial for assessing patients’ experiences in the healthcare system. Both clinically and theoretically, patient-centered consultations are essential in patient-care, and are often ...
Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group   +15 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Population health profile of the Northern Melbourne Division of General Practice [PDF]

, 2005
© Commonwealth of Australia To view the data presented in the profiles in Excel spreadsheets or via Interactive Mapping, please see the PHIDU website at: www.publichealth.gov ...
Ambrose, S., Fisher, E., Glover, J., Hutchison, A., Leahy, K.   +4 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Core Values and Principles of Nordic General Practice/Family Medicine

Scandinavian Journal of Primary Health Care, 2020
Nordic Federation of General Practice (NFGP)
doaj   +1 more source

Patterns and Adherence to GOLD-Recommended Inhaled Therapy in Chronic Obstructive Pulmonary Disease (COPD) Patients with Acute Exacerbation History in Primary Care in China

International Journal of COPD
Hongjing Pei,1 Yujing Su,1 Guanning Jing,1,2 Qiaoli Su,3 Jiao Xu,4 Xue Jin,1 Jingyu Hao,1 Jiapei Xu,1 Jianhua Chen,1 Xueying Li,5 Jing Ma,6 Ying Wang,1 Jingyi Ye,1 Mi Yao,1,2 Chunhua Chi1,2,7,8 1Department of General Practice, Peking University First ...
Pei H, Su Y, Jing G, Su Q, Xu J, Jin X, Hao J, Xu J, Chen J, Li X, Ma J, Wang Y, Ye J, Yao M, Chi C   +14 more
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Exosomes as Emerging Regulators of Immune Responses in Type 2 Diabetes Mellitus

Journal of Diabetes Research
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by high blood glucose levels resulting from insulin resistance and impaired insulin secretion. Immune dysregulation-mediated chronic low-grade inflammation is a critical factor
Wei Zheng, Xin Ji, Qiao qiao Yin, Chensi Wu, Chengan Xu, Hongying Pan, Chun Wu   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Machine Learning-Driven Prediction of One-Year Readmission in HFrEF Patients: The Key Role of Inflammation

Clinical Interventions in Aging
Fanghui Ma,* Yue Hu,* Ping Han, Yan Qiu, Ying Liu, Jingjing Ren Department of General Practice, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China*These authors contributed ...
Ma F, Hu Y, Han P, Qiu Y, Liu Y, Ren J
doaj