Results 91 to 100 of about 8,173,281 (311)

A study of general practice consultations at Mosta Health Centre, Malta [PDF]

, 2013
Primary care is the first contact for patients with health related problems. In Malta, primary health is provided by both private and state sectors. The state services are free-of-charge and provide a 24 hrs walk-in GP service at health centres as ...
Cuschieri, Sarah, Sammut, Mario R.
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Association Between Metabolic Scores for Visceral Fat and Arterial Stiffness

Vascular Health and Risk Management
Fang Liu,1,2,* Beijia Lin,3,* Wenhui Huang,1,2 Yangfan Hu,1,2 Ziheng Wu,4 Guoyan Xu,1,2,5 Liangdi Xie,1,2,5– 8 Tingjun Wang1,2,5,8 1Department of General Practice, The First Affiliated Hospital, Fujian Medical University, Fuzhou, People’s
Liu F, Lin B, Huang W, Hu Y, Wu Z, Xu G, Xie L, Wang T   +7 more
doaj  

Optimal care at the end of life (OPAL): study protocol of a prospective interventional mixed-methods study with pretest-posttest-design in a primary health care setting considering the view of general practitioners, relatives of deceased patients and health care stakeholders

BMC Health Services Research, 2019
Background At the end of life, about 85–90% of patients can be treated within primary palliative care (PC) provided by general practitioners (GPs). In Germany, there is no structured approach for the provision of PC by GPs including a systematic as well ...
Kambiz Afshar, Gabriele Müller-Mundt, Katharina van Baal, Sophie Schrader, Birgitt Wiese, Jutta Bleidorn, Stephanie Stiel, Nils Schneider   +7 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

MDT Reduces Perioperative Thrombotic Events in Elderly Orthopedic Patients

Journal of Multidisciplinary Healthcare
Tonghua Chen,1,* Xiaojun Lei,1,* Jingwei Tian,1,* Haochen Mai,1 Yuanfang Yu,1 Wenxia Wu,1 Liqiang Wen,1 Phei Er Saw,1 Meng Zhang1,2 1Department of General Practice, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou,
Chen T, Lei X, Tian J, Mai H, Yu Y, Wu W, Wen L, Saw PE, Zhang M   +8 more
doaj  

Prevalence and risk factors of airflow obstruction in Southwest China: baseline findings from a multi-center population-based cohort study

BMC Pulmonary Medicine
Background Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder primarily characterized by persistent airflow obstruction.
Yao Lv, Xiaolong Tang, Shanye Yi, Yu Jia, Bojiang Chen, Jun Shao, Jieling Li, Yi Yao, Jing Xiong, Miaomiao Wu, Wenjun Fu, Jingxin Ma, Rui Zhang, Weimin Li, Yi Lei   +14 more
doaj   +1 more source

Managing medically unexplained illness in general practice [PDF]

Provides practical management strategies that general practitioners (GPs) can use when patients present with medically unexplained symptoms. Background Patients with medically unexplained symptoms commonly present to general practice and experience ...
Louise Stone
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source