Results 91 to 100 of about 16,433,437 (314)

Co-design and validation of a tool for monitoring and improving the quality of general practice learning environments

BMC Health Services Research
Background Continuous quality improvement of general practice learning environments is critical for training the next generation of general practitioners (GPs).
Samia Toukhsati, Belinda O’Sullivan, Tina George, Leila Greenfield, Simon Morgan, Rebecca Kippen, Carla Taylor   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Continuity of care in general practice and secondary care: retrospective cohort study

Background Better continuity in primary and secondary care is linked to improved health outcomes, but it is unclear whether the sociodemographic determinants of continuity are the same in both settings and whether continuity measures in each setting are ...
Majeed, Azeem, Woodcock, Thomas, Clarke, Jonathan, Aylin, Paul, Beaney, Thomas   +4 more
core   +1 more source

Skin cancer medicine integral to Australian general practice

, 2019
Skin cancer medicine is a core component of Australian general practice and is consistently in the top 10 conditions managed.1 This is not surprising as Australia has the highest incidence of melanoma in the world,2 leaving melanoma the fourth most ...
Margolis, SA
core   +1 more source

Estimated prevalence of people with learning disabilities: template for general practice [PDF]

, 2008
BACKGROUND In 2001, a white paper set out a commitment to ensure that people with a learning disability receive equal access to health services, with an expectation that general practices would have identified all people with a learning disability ...
Cottrell, D., Allgar, V., Mir, Ghazala, Marshall, Joyce, Evans, Joyce, Emerson, E., Emerson, Eric, Mir, G., Marshall, J., Heywood, P., Evans, J., Allgar, Victoria, Cottrell, David, Heywood, Phil   +13 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The prognosis of low back pain in general practice [PDF]

, 1997
Study Design. A prospective cohort study on low back pain in consecutive patients in general practice, in which potential prognostic indicators at baseline and at the 1-year follow-up examination were assessed by means of four weekly questionnaires ...
Koes, B.W., Deville, W.L.J.M., Van Eijk, Jacques T.M., Koes, Bart W.; id_orcid, Hoogen, H.J.M. van den, Bouter, L.M.; id_orcid, Devillé, Walter, Bouter, L.M., Van Den Hoogen, Hans J.M., Eijk, J.T.M. van, Koes, Bart W., van Eijk, J.T.M., Bouter, Lex M., van den Hoogen, H.J.M.   +13 more
core   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Women's healthcare service in General Practice: a national survey of current service provisions and attitudes of Irish General Practitioners.

, 2000
Women's healthcare is a priority for government, for medical professionals and, of course, for women themselves. General practitioners will playa central role in the provision of an expanded service.
Ni Riain, Ailis, Canning, Philomena
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source