Results 71 to 80 of about 8,173,281 (311)

Dismantling general practice [PDF]

open access: yesBritish Journal of General Practice, 2007
Twenty years ago general practice in the UK was frequently and justifiably described as the jewel in the crown of the NHS.1 GPs led primary health care teams which provided comprehensive, continuous, coordinated, and personal care for registered patient populations, and exercised a benign gate-keeping role by regulating patients' access to more ...
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Teaching general practice [PDF]

open access: yesBritish Journal of General Practice, 2019
Andrew Blythe’s recent editorial on teaching general practice reminds us of the opportunities to teach diagnostic reasoning, the management of uncertainty, and therapeutics, which appear under-taught in many schools.1,2 There is also an opportunity here for a patient safety focus in consulting, in terms of discussing diagnostic reasoning, …
openaire   +2 more sources

Emergency supply of prescription-only medicines to patients by community pharmacists: a mixed methods evaluation incorporating patient, pharmacist and GP perspectives [PDF]

open access: yes, 2015
Objective To evaluate and inform emergency supply of prescription-only medicines by community pharmacists (CPs), including how the service could form an integral component of established healthcare provision to maximise adherence. Design Mixed methods.
Ashcroft, Darren M   +7 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Entering general practice [PDF]

open access: yesBritish Journal of General Practice, 2008
Congratulations on publishing Daniel Furmedge's telling short paper.1 Full marks for his insight and interpretation. He reminded me of my first Claire Wand Fund Prize on ‘Postgraduate education …
openaire   +2 more sources

kurz und kn@pp news : Nr. 13 [engl. Fassung] [PDF]

open access: yes, 2008
* The Professionalization of General Practice * 42nd Congress of the DEGAM German Society of General Practice and Family Medicine * Online Registration for students now possible * Opera tickets for participants in the PRoMPT study ...

core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Access to primary care and the route of emergency admission to hospital: retrospective analysis of national hospital administrative data [PDF]

open access: yes, 2015
BACKGROUND: The UK government is pursuing policies to improve primary care access, as many patients visit accident and emergency (A and E) departments after being unable to get suitable general practice appointments.
Bottle, A   +8 more
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

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