Results 71 to 80 of about 16,433,437 (314)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Availability of point-of-care culture and microscopy in general practice - does it lead to more appropriate use of antibiotics in patients with suspected urinary tract infection?

European Journal of General Practice, 2020
Background Urinary tract infection (UTI) is a common condition in general practice, and urine culture can help reduce inappropriate antibiotic prescriptions. In case of delay of the result, antibiotic treatment can be guided by one or more point-of-care (
Anne Holm, Volkert Siersma, Lars Bjerrum, Gloria Cordoba   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

CHILDBIRTHS IN GENERAL PRACTICE. [PDF]

The Lancet, 1882
n ...
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dublin area Hepatitis C in General Practice Initiative: report of a Pilot Implementation Programme in Eastern Regional Health Authority.

, 2003
Hepatitis C (HCV) is a common and potentially serious infection affecting people who have injected or who continue to inject drugs. Addiction treatment services for injecting drug users have expanded considerably in Ireland Since 1993, with general ...
Cullen, Walter
core  

Rationalising data use for general practice: a missed opportunity? [PDF]

, 2016
Rationalising Data Use for General Practice: A Missed ...
Louis S. Levene (7625291), Andrew Douglas Wilson (7647995), Baker, R, Richard Baker (301808), K. Honeyford (7647998), Walker, N, Nicola Walker (30591), Levene, LS, Wilson, A, Honeyford, C   +9 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Consultations for sexually transmitted infections in the general practice in the Netherlands: an opportunity to improve STI/HIV testing. [PDF]

, 2013
Objectives: In the Netherlands, sexually transmitted infection (STI) care is provided by general practitioners (GPs) as well as by specialised STI centres. Consultations at the STI centres are monitored extensively, but data from the general practice are
Donker, G.A., van Bergen, Jan E. A. M., Trienekens, Suzan C. M., Broek, I.V.F. van den, Bergen, Jan E A M van, Sande, Marianne A B van der, Trienekens, Suzan C M, van den Broek, Ingrid V. F., Donker, Gé A., Bergen, J.E.A.M. van, Donker, Gé A, Trienekens, S.C.M., Sande, M.A.B. van der, van der Sande, Marianne A. B., Broek, Ingrid V F van den   +14 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source