Results 131 to 140 of about 16,433,437 (314)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Exosomes as Emerging Regulators of Immune Responses in Type 2 Diabetes Mellitus

Journal of Diabetes Research
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by high blood glucose levels resulting from insulin resistance and impaired insulin secretion. Immune dysregulation-mediated chronic low-grade inflammation is a critical factor
Wei Zheng, Xin Ji, Qiao qiao Yin, Chensi Wu, Chengan Xu, Hongying Pan, Chun Wu   +6 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A participant-observer case study of research in isolated Australian rural general practice

, 2003
Author's previously published works appended.Bibliography: p. 291-326.The subject of this thesis is a single participant-observer case study which demonstrates the feasibility of integrating research activity within the daily routine of patient care in a
Watts, Richard Walter
core  

Machine Learning-Driven Prediction of One-Year Readmission in HFrEF Patients: The Key Role of Inflammation

Clinical Interventions in Aging
Fanghui Ma,* Yue Hu,* Ping Han, Yan Qiu, Ying Liu, Jingjing Ren Department of General Practice, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China*These authors contributed ...
Ma F, Hu Y, Han P, Qiu Y, Liu Y, Ren J
doaj  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

General Practice [PDF]

Journal of the Royal Army Medical Corps, 2005
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The management of chronic neck pain in general practice

, 1999
Objective - To describe the management in patients with chronic non- specific neck pain in general practice. Design - A descriptive, questionnaire-based retrospective study. Setting - General practices in the Netherlands.
Janssen, H, Koes, B.W., Borghouts, J.A.J., Janssen, H.A.M., Muris, J.W.M., Bouter, Lex, Janssen, Henriëtte, Muris, Jean, Koes, Bart; id_orcid, Bouter, L, Metsemakers, Job, Bouter, L.M.; id_orcid, Koes, Bart, Borghouts, Jeroen, Bouter, L.M., Borghouts, J, Metsemakers, J.F.M., Metsemakers, J, Koes, B, Muris, J; id_orcid   +19 more
core   +1 more source