Results 71 to 80 of about 1,892,611 (268)

MDT Reduces Perioperative Thrombotic Events in Elderly Orthopedic Patients

Journal of Multidisciplinary Healthcare
Tonghua Chen,1,* Xiaojun Lei,1,* Jingwei Tian,1,* Haochen Mai,1 Yuanfang Yu,1 Wenxia Wu,1 Liqiang Wen,1 Phei Er Saw,1 Meng Zhang1,2 1Department of General Practice, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou,
Chen T, Lei X, Tian J, Mai H, Yu Y, Wu W, Wen L, Saw PE, Zhang M   +8 more
doaj  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

‘I’ve put diabetes completely on the shelf till the mental stuff is in place’. How patients with doctor-assessed impaired self-care perceive disease, self-care, and support from general practitioners. A qualitative study

Scandinavian Journal of Primary Health Care, 2018
Objective: This paper investigated patients’ experiences of disease and self-care as well as perceptions of the general practitioner’s role in supporting patients with impaired self-care ability.
Mads Aage Toft Kristensen, Ann Dorrit Guassora, Anne Beiter Arreskov, Frans Boch Waldorff, Bibi Hølge-Hazelton   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Patterns and Adherence to GOLD-Recommended Inhaled Therapy in Chronic Obstructive Pulmonary Disease (COPD) Patients with Acute Exacerbation History in Primary Care in China

International Journal of COPD
Hongjing Pei,1 Yujing Su,1 Guanning Jing,1,2 Qiaoli Su,3 Jiao Xu,4 Xue Jin,1 Jingyu Hao,1 Jiapei Xu,1 Jianhua Chen,1 Xueying Li,5 Jing Ma,6 Ying Wang,1 Jingyi Ye,1 Mi Yao,1,2 Chunhua Chi1,2,7,8 1Department of General Practice, Peking University First ...
Pei H, Su Y, Jing G, Su Q, Xu J, Jin X, Hao J, Xu J, Chen J, Li X, Ma J, Wang Y, Ye J, Yao M, Chi C   +14 more
doaj  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Core Values and Principles of Nordic General Practice/Family Medicine

Scandinavian Journal of Primary Health Care, 2020
Nordic Federation of General Practice (NFGP)
doaj   +1 more source

Machine Learning-Driven Prediction of One-Year Readmission in HFrEF Patients: The Key Role of Inflammation

Clinical Interventions in Aging
Fanghui Ma,* Yue Hu,* Ping Han, Yan Qiu, Ying Liu, Jingjing Ren Department of General Practice, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China*These authors contributed ...
Ma F, Hu Y, Han P, Qiu Y, Liu Y, Ren J
doaj  

Implementation and acceptability of the Caregiver Care Model in general practice: a mixed-method feasibility study

BMC Primary Care
Background Being a caregiver can be demanding. Therefore, we developed the Caregiver Care Model for general practice. The model consists of a mandatory dialogue questionnaire, which is used to identify support needs in caregivers, grief-facilitating ...
Mette Kjaergaard Nielsen, Marie Cecilie Vinther, Mai-Britt Guldin, Kaj Sparle Christensen, Anna Mygind   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source