Results 41 to 50 of about 869,087 (312)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

General scientific guidance for stakeholders on health claim applications

open access: yesEFSA Journal, 2016
The European Food Safety Authority (EFSA) asked the Panel on Dietetic Products Nutrition and Allergies (NDA) to update the General guidance for stakeholders on the evaluation of Article 13.1, 13.5 and 14 health claims published in March 2011. Since then,
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
doaj   +1 more source

General principles of treatment

open access: yesAnnals of Oncology, 2007
Treatment decisions depend not only on several factors, which may be summarized as follows: impact of disease, efficacy of the therapy and potential side-effects, but also on whether the disease has metastasized or not. As discussed in the previous chapters, hematological malignancies are generally systemic at diagnosis.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

On the Architecture of Systemology and the Typology of Its Principles

open access: yesSystems, 2018
Systems engineering is increasingly challenged by the rising complexity of projects undertaken, resulting in increases in costs, failure rates, and negative unintended consequences.
David Rousseau
doaj   +1 more source

General principles of carotid Doppler ultrasonography [PDF]

open access: yesUltrasonography, 2014
<p>Carotid Doppler ultrasonography is a popular tool for evaluating atherosclerosis of the carotid artery. Its two-dimensional gray scale can be used for measuring the intima-media thickness, which is very good biomarker for atherosclerosis
Whal Lee
doaj   +1 more source

The Principle of General Tovariance [PDF]

open access: yesAIP Conference Proceedings, 2008
We tentatively propose two guiding principles for the construction of theories of physics, which should be satisfied by a possible future theory of quantum gravity. These principles are inspired by those that led Einstein to his theory of general relativity, viz.
C. Heunen   +4 more
openaire   +3 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Critical Analysis of the General Principles of Sentencing under the Criminal Law Doctrine and Their Application by the Supreme Court of the Russian Federation

open access: yesУченые записки Казанского университета: Серия Гуманитарные науки
This article highlights the need to enhance the procedures for determining guilt through criminal law. The study is based on a careful analysis of the legal standards laid down in the Criminal Code of the Russian Federation and key academic sources of ...
L. R. Safin
doaj   +1 more source

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