Results 61 to 70 of about 869,087 (312)

Chronic pancreatitis: general principles of treatment

open access: yesGastroenterologìa, 2018
The literature review considers the problems of the treatment of abdominal pain syndrome, pancreatic exocrine insufficiency syndrome, chronic pancreatitis of Oddi’s sphincter dysfunction, disorders of gall bladder, bile ducts, dysbiosis, intestinal ...
T.N. Hristich, D.O. Hontsariuk
doaj   +1 more source

General principles of chemotherapy.

open access: yesEuropean review for medical and pharmacological sciences, 2010
Over the last 50 years, medical treatment of solid cancers gained major advances in terms of effectiveness through breakthrough knowledge of cancer biology, technology development and identification of fundamental active drugs.We conventionally discriminate between medical treatment of the advanced or metastatic disease and of the early disease, namely
RICEVUTO, Enrico, Bruera G, Marchetti P.
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

The Simplicity of Existence in Transcendent and Peripatetic Philosophies [PDF]

open access: yesحکمت اسرا, 2015
The general principles have an important role in agreement or disagreement in philosophical theories. "The simplicity of existence" is one of the principles that Mulla Sadra projected in general principles against Peripatetic philosophy. So, the question
mohammad abbas zadeh   +1 more
doaj  

Generalizing the Taylor Principle: Comment [PDF]

open access: yesAmerican Economic Review, 2008
Troy Davig and Eric Leeper (2007) have proposed a condition they call the generalized Taylor principle to rule out indeterminate equilibria in a version of the new-Keynesian model where the parameters of the policy rule follow a Markov-switching process.
Roger E. A. Farmer   +2 more
openaire   +4 more sources

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Principles of Federal Appropriations Law: Second Edition, Volume IV [PDF]

open access: yes, 2001
Other written product issued by the General Accounting Office with an abstract that begins "GAO published a second edition of Volume IV of its Principles of Federal Appropriations Law, Second Edition, which includes a discussion of the statutes and ...
United States. General Accounting Office.
core  

General principles of law /

open access: yes, 2020
"Examining general principles of law provides one of the most instructive examples of the intersection between EU law and comparative law. This collection draws on the expertise of high-profile and distinguished scholars to provide a critical examination
Vogenauer, Stefan,, Weatherill, Stephen,
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Principles forensic expertise reduced general working ability [PDF]

open access: yesGlasnik Advokatske komore Vojvodine, 2017
In practice, the concept of general working ability is often equated with the lifestyle activity. It is customary that the general ability involves generalized possibility of performing certain tasks in the labour market that are not related to the ...
Govedarica Veselin   +2 more
doaj   +1 more source

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