Results 81 to 90 of about 12,736,386 (305)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Foro Virtual sobre Régimen General de Origen : informe final
, 2009 ALADI.
ALADI. Secretaría General
core +1 more source
The Volterra Principle Generalized [PDF]
Philosophy of Science, 2017 Michael Weisberg and Kenneth Reisman argue that the Volterra Principle can be derived from multiple predator-prey models and that, therefore, the Volterra Principle is a prime example for robustness analysis. In the current article, I give new results regarding the Volterra Principle, extending Weisberg’s and Reisman’s work, and I discuss the ...
openaire +2 more sources
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
The Operating Principles of Public Service
Journal of Danubian Studies and Research, 2012 A public service has always been an activity of public interest managed by the publicadministration. There are many operating rules of public services. Some of these rules, the most significant ones, are generally seen as general principles, such as the ...
Maria Orlov, Vlad Cantir
doaj
Some general principles in tropical convexities
ESAIM: Proceedings and Surveys, 2017 We present what the title says with an emphasis on separation and topological properties as they relate to some of the fundamental principles of nonlinear analysis.
Horvath Charles
doaj +1 more source
Principles of Federal Appropriations Law: Second Edition, Volume IV [PDF]
, 2001 Other written product issued by the General Accounting Office with an abstract that begins "GAO published a second edition of Volume IV of its Principles of Federal Appropriations Law, Second Edition, which includes a discussion of the statutes and ...
United States. General Accounting Office.
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source