Results 71 to 80 of about 713,409 (264)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Some general principles in tropical convexities
ESAIM: Proceedings and Surveys, 2017 We present what the title says with an emphasis on separation and topological properties as they relate to some of the fundamental principles of nonlinear analysis.
Horvath Charles
doaj +1 more source
Principles of General Ecology.
Bulletin of the Torrey Botanical Club, 1954 Includes bibliography. ; Mode of access: Internet.
openaire +2 more sources
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
The Operating Principles of Public Service
Journal of Danubian Studies and Research, 2012 A public service has always been an activity of public interest managed by the publicadministration. There are many operating rules of public services. Some of these rules, the most significant ones, are generally seen as general principles, such as the ...
Maria Orlov, Vlad Cantir
doaj
Principles of Preventive Police Activity: Concepts, Content and Their Classification
Law and Safety, 2019 The author of the article has studied the scientific positions of scholars on understanding and classification of the principles of law. The characteristic features of the principles of preventive police activity have been distinguished.
S. O. Shatrava, H. R. Parkhanov
doaj +1 more source
Generalizing Landauer’s principle [PDF]
Physical Review E, 2009 In a recent paper [Mar05] it is argued that to properly understand the thermodynamics of Landauer's Principle it is necessary extend the concept of logical operations to include indeterministic operations. Here we examine the thermodynamics of such operations in more detail, extending the work of Landuaer[Lan61] to include indeterministic operations ...
openaire +3 more sources
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source