Results 121 to 130 of about 6,497,246 (364)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

The Singularity Theorems of General Relativity and Their Low Regularity Extensions. [PDF]

Jahresber Dtsch Math Ver, 2023
Steinbauer R.
europepmc   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Shrodinger Equation in General Relativity

Journal of Mathematical and Fundamental Sciences, 2019
. Dalam tulisan ini diturunkan persamaan Schrodinger ke dalam TRU dari suatu partikel bermuatan dalam potensial Coulomb, yang diperoleh sebagai approksimasi dari pada persamaan Klein-Gordon dalam TRU dengan anggapan bahwa energi kinetik dan potensialnya ...
Hans J. Wospakrik
doaj  

Rotating Quark Stars in General Relativity

Universe, 2018
We have built quasi-equilibrium models for uniformly rotating quark stars in general relativity. The conformal flatness approximation is employed and the Compact Object CALculator (cocal) code is extended to treat rotating stars with surface density ...
Enping Zhou, Antonios Tsokaros, Luciano Rezzolla, Renxin Xu, Kōji Uryū   +4 more
doaj   +1 more source

Testing general relativity with cosmological large scale structure. [PDF]

Gen Relativ Gravit, 2022
Durrer R.
europepmc   +1 more source

Geometric Analysis and General Relativity

, 2005
This article discusses methods of geometric analysis in general relativity, with special focus on the role of "critical surfaces" such as minimal surfaces, marginal surface, maximal surfaces and null surfaces.Comment: to appear in Elsevier Encyclopedia ...
Andersson, Lars
core  

Relativity. The Special and General Theory. [PDF]

, 1921
J. E. Trevor, Albert Einstein, ROBERT W. LAWSON   +2 more
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

General Relativity and the AKSZ Construction. [PDF]

Commun Math Phys, 2021
Canepa G, Cattaneo AS, Schiavina M.
europepmc   +1 more source