Results 101 to 110 of about 7,004,183 (346)

High-precision Relativistic Timescales for Cislunar Navigation

open access: yesThe Astrophysical Journal
We present a unified post-Newtonian framework for relativistic timing and coordinate transformations across the Barycentric, Geocentric, and Lunicentric Celestial Reference Systems ( LCRS ) and six timescales: Barycentric Coordinate Time ( TCB ...
Slava G. Turyshev
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The Relativistic Spin Precession in the Compact Double Neutron Star System PSR J1946+2052

open access: yesThe Astrophysical Journal
We observe systematic profile changes in the visible pulsar of the compact double neutron star system PSR J1946+2052 using observations with the Five-hundred-meter Aperture Spherical radio Telescope (FAST). The interpulse of PSR J1946+2052 changed from a
Lingqi Meng   +18 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Change in Hamiltonian General Relativity from the Lack of a Time-like Killing Vector Field [PDF]

open access: yes, 2013
In General Relativity in Hamiltonian form, change has seemed to be missing, defined only asymptotically, or otherwise obscured at best, because the Hamiltonian is a sum of first-class constraints and a boundary term and thus supposedly generates gauge ...
Pitts, J. Brian, J. Brian Pitts
core  

On Conformally Coupled General Relativity

open access: yesEPJ Web of Conferences, 2018
A gravity model based on the conformal symmetry is presented. To specify the structure of the general coordinate transformations the Ogievetsky theorem is applied. The nonlinear symmetry realization approach is used.
Arbuzov Andrej, Latosh Boris
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Black holes: do they exist?

open access: yesZagadnienia Filozoficzne w Nauce, 2018
Black holes entered scientific literature as early as at the end of eighteenth century. They had been known at that time as dark stars, but their concept did not find its way to physics or astronomy, and had been abandoned for more than one hundred years.
Edward Malec
doaj  

Generating Matter Inhomogeneities in General Relativity [PDF]

open access: yesPhysical Review Letters, 2012
This is the longer version of the article that appeared in Phys. Rev. Lett. 108, 191101 (2012)
Coley, Alan, Lim, Woei Chet
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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