Results 131 to 140 of about 10,399,375 (306)

The genesis of general relativity

open access: yes, 2007
This four-volume work represents the most comprehensive documentation and study of the creation of general relativity; one of the fundamental physical theories of the 20th century.
Stachel, John   +4 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

General relativity and geodesy

open access: yesInternational Journal of Modern Physics D
Mass redistribution on Earth due to dynamic processes such as ice melting and sea-level rise leads to a changing gravitational field, observable by geodetic techniques. Monitoring this change over time allows us to learn more about our planet and its dynamic evolution.
Eva Hackmann   +4 more
openaire   +2 more sources

Coordinates, observables and symmetry in relativity [PDF]

open access: yes, 2007
We investigate the interplay and connections between symmetry properties of equations, the interpretation of coordinates, the construction of observables, and the existence of physical relativity principles in spacetime theories. Using the refined notion
Westman, Hans   +3 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

How Hume and Mach Helped Einstein Find Special Relativity [PDF]

open access: yes, 2004
In recounting his discovery of special relativity, Einstein recalled a debt to the philosophical writings of Hume and Mach. I review the path Einstein took to special relativity and urge that, at a critical juncture, he was aided decisively not by any ...
John D. Norton   +2 more
core  

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