Results 151 to 160 of about 10,399,375 (306)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Numerical Hydrodynamics in General Relativity
Living Reviews in Relativity, 2003 The current status of numerical solutions for the equations of ideal general relativistic hydrodynamics is reviewed. With respect to an earlier version of the article, the present update provides additional information on numerical schemes, and extends ...
Font José A.
doaj
Are General Relativity and Teleparallel Gravity Theoretically Equivalent?
Philosophy of PhysicsTeleparallel gravity shares many qualitative features with general relativity, but differs from it in the following way: whereas in general relativity, gravitation is a manifestation of spacetime curvature, in teleparallel gravity, spacetime is (always)
James Owen Weatherall, Helen Meskhidze
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Numerical Hydrodynamics in General Relativity
Living Reviews in Relativity, 2000 The current status of numerical solutions for the equations of ideal general relativistic hydrodynamics is reviewed. Different formulations of the equations are presented, with special mention of conservative and hyperbolic formulations well-adapted to ...
Font José A.
doaj
Spacetime Emergence: An (In)effective Story
Philosophy of PhysicsPhysicists and philosophers are increasingly prone to regarding our current physical theories as providing ‘effective descriptions’ of real-world systems.
Mike D. Schneider
doaj +1 more source
Some Thoughts on Relativity and the Flow of Time: Einstein's Equations given Absolute Simultaneity [PDF]
, 2004 The A-theory of time has intuitive and metaphysical appeal, but suffers from tension, if not inconsistency, with the special and general theories of relativity (STR and GTR).
Pitts, J. Brian
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source