Results 71 to 80 of about 9,621 (262)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Tests of Gravity Using Lunar Laser Ranging

Living Reviews in Relativity, 2010
Lunar laser ranging (LLR) has been a workhorse for testing general relativity over the past four decades. The three retroreflector arrays put on the Moon by the Apollo astronauts and the French built arrays on the Soviet Lunokhod rovers continue to be ...
Stephen M. Merkowitz
doaj  

Is General Relativity Really General Relativity?

In this short paper we briefly discuss the issue of the theory of general relativity as a supposed generalization of the theory of special relativity to see if general relativity did really generalize special relativity as a relativity theory. The simple conclusion that we reach in this discussion is that the theory of general relativity is not ...
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

General relativity and geodesy

International Journal of Modern Physics D
Mass redistribution on Earth due to dynamic processes such as ice melting and sea-level rise leads to a changing gravitational field, observable by geodetic techniques. Monitoring this change over time allows us to learn more about our planet and its dynamic evolution.
Eva Hackmann, Moritz Huckfeldt, Claus Lämmerzahl, Dennis Philipp, Benny Rievers   +4 more
openaire   +2 more sources

Mathematical general relativity [PDF]

General Relativity and Gravitation, 2019
We present a number of open problems within general relativity. After a brief introduction to some technical mathematical issues and the famous singularity theorems, we discuss the cosmic censorship hypothesis and the Penrose inequality, the uniqueness of black hole solutions and the stability of Kerr spacetime and the final state conjecture, critical ...
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

General Relativity by Kawaguchi geometry

EPJ Web of Conferences, 2013
We construct a parameterisation invariant Lagrange theory of fields up to second order by using multivector bundles and Kawaguchi geometry. In this setup, the spacetime is an dynamical object which is a submanifold of the greater manifold, and the actual
Tanaka Erico
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Structural Stability and General Relativity

Universe
We review recent developments in structural stability as applied to key topics in general relativity. For a nonlinear dynamical system arising from the Einstein equations by a symmetry reduction, bifurcation theory fully characterizes the set of all ...
Spiros Cotsakis
doaj   +1 more source