Results 151 to 160 of about 1,814,913 (312)
A general slip-line field solution for the ultimate bearing capacity of a pipeline on drained soils
, 2015 An accurate evaluation of the ultimate bearing capacity of a cylindrical foundation is crucial for predicting pipe-soil interaction behaviors. A general slip-line field solution is derived for the ultimate bearing capacity of a pipeline on the drained ...
Wang N +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Non-cooperative Support for the Asymmetric Nash Bargaining solution
Our work contributes to the game-theoretic analysis of bargaining by providing additional non-cooperative support to the well-known Nash bargaining solution.
Herings, P. Jean-Jacques +2 more
core
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
General solutions of weakly delayed discrete systems in 3D
Advances in Nonlinear AnalysisDiscrete systems x(k+1)=Ax(k)+Bx(k−m)x\left(k+1)=Ax\left(k)+Bx\left(k-m), k=0,1,…k=0,1,\ldots \hspace{0.33em} are analyzed, where mm is a fixed positive integer, AA, BB are constant 3 by 3 matrices and x:{−m,−m+1,…}→R3x:\left\{-m,-m+1,\ldots \right\}\to {
Diblík Josef +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Country Portfolio Dynamics [PDF]
This paper presents a general approximation method for characterizing timevarying equilibrium portfolios in a two-country dynamic general equilibrium model.
Michael B Devereux, Alan Sutherland
core
Ante-factum legislative general vaccination mandates as a solution to legal hypocrisy in pandemics [PDF]
With the next pandemic likely not far off, the debate over the suitability of a broad, general vaccination mandate (GVM) goes on. This essay proposes a novel argument in favor of GVM—one based on the reality that left to its own devices, executive power,
Radavoi, Ciprian N.
core +1 more source