Results 131 to 140 of about 15,159,360 (304)

On the Dynamics of Some Higher-Order Nonlinear Difference Equations

Mathematics
This research investigates the dynamics of higher-order nonlinear difference equations, specifically concentrating on seventh-order instances. Analytical solutions are obtained for particular equations, a formidable task owing to the absence of explicit ...
Turki D. Alharbi, Md Rifat Hasan
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Arbitrariness of the General Solution and Symmetries

Acta Applicandae Mathematicae, 1995
Results of the author [J. Math. Phys. 35, No. 1, 486-498 (1994; Zbl 0803.35143)] concerning the computation of the number of arbitrary functions in the general solution of a system of involutive PDEs are briefly reviewed. They are used to study normal systems and their symmetry reductions. The computation of the number of physical degrees of freedom in
openaire   +5 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

General Fund, Transportation Fund and spending cap projections; General Fund and Transportation Fund budget projections and fiscal information; General Fund & Transportation Fund budget projections

, 2010
Two or three issues a year; Vol. for FY 07/FY 09 General Fund covers FY 07/FY 12 Transportation Fund budget projections.; Harvested from the web on 9/30 ...

core   +1 more source

First Integral and General Solution of the Reduced Nonlinear Third-Order Differential Equation with a Nonlinear Source

Mathematics
We consider a generalization of the modified Korteweg–de Vries–Burgers equation with a nonlinear source. Using the Painlevé test for partial differential equation with the Kruskal variable, we show that the corresponding Cauchy problem cannot be solved ...
Nikolay A. Kudryashov
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Solution-Focused Collective Action: A Response to Harry Korman, Peter De Jong, and Sara Smock Jordan

, 2021
The July 2021 edition of this journal carried both a response (Shennan, 2021) to the article Steve de Shazer’s Theory Development (Korman et al., 2020), and a reply to that response by the article’s authors (Korman et al., 2021). These authors gave their
Collective, Solution-Focused
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source