Results 81 to 90 of about 743,035 (307)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Grounded theory methodology as a resource for pluralist information systems research [PDF]
, 2019 MIS Quarterly recently published an extensive review of the Grounded Theory Methodology (GTM) in Information Systems research (Wiesche et al., 2017).
Lanamäki, Arto, Haj-Bolouri, Amir
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Entropy and information causality in general probabilistic theories
New Journal of Physics, 2010 We investigate the concept of entropy in probabilistic theories more general than quantum mechanics, with particular reference to the notion of information causality recently proposed by Pawlowski et. al. (arXiv:0905.2992). We consider two entropic quantities, which we term measurement and mixing entropy. In classical and quantum theory, they are equal,
Barnum, Howard +7 more
openaire +6 more sources
Fundamental Limits of Wideband Localization - Part I: A General Framework
, 2008 The availability of position information is of great importance in many commercial, public safety, and military applications. The coming years will see the emergence of location-aware networks with submeter accuracy, relying on accurate range ...
Shen, Yuan, Win, Moe Z.
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
A Synergetic Theory of Information
, 2019 A new approach is presented to defining the amount of information, in which information is understood as the data about a finite set as a whole, whereas the average length of an integrative code of elements serves as a measure of information.
Viktor Vyatkin
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
On a Connection between Information and Group Lattices
Entropy, 2011 In this paper we review a particular connection between information theory and group theory. We formalize the notions of information elements and information lattices, first proposed by Shannon.
Edwin K. P. Chong, Hua Li
doaj +1 more source
, 2000 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This dissertation focuses on the mathematical design of a unified shape kernel for geometric computing, with possible applications to computer aided design (
Gomes, Abel Joao Padrao
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