Results 91 to 100 of about 743,035 (307)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A GENERALIZATION OF SHANNON'S INFORMATION THEORY

International Journal of General Systems, 1999
A generalized information theory is proposed as a natural extension of Shannon's information theory. It proposes that information comes from forecasts. The more precise and the more unexpected a forecast is, the more information it conveys. If subjective forecast always conforms with objective facts then the generalized information measure will be ...
openaire   +2 more sources

The Development of Information Science in Ibero-America [PDF]

, 2021
The purpose of this article is to problematize the existence of a possible Ibero-American informational thinking. It was initially observed that a relative absence of Ibero-America in the international presentations and mappings of information science ...
Ávila Araújo, Carlos Alberto
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

General balance, combination of information and the analysis of covariance

, 1992
A resume is given of the conditions and underlying theory for general balance of an experimental design, paying particular attention to their relationships to the usual linear models for analysis of variance and the marginality relationships between the ...
Tobias, R. D., Payne, R. W.
core  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Scaling behaviour and critical phase transitions in integrated information theory [PDF]

, 2019
Integrated Information Theory proposes a measure of conscious activity (Phi), characterised as the irreducibility of a dynamical system to the sum of its components. Due to its computational cost, current versions of the theory (IIT 3.0) are difficult to
Miguel Aguilera, Aguilera, Miguel
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The structure and concept of the theory of bibliography

Knygotyra
M. Briskman's, E. Bespalova's, O. Korshunov's, and L. Lelikova's viewpoints on the concept of the theory of bibliography are examined. The theory of bibliography should be more strictly differentiated from other kinds of scientific information.
Osvaldas Janonis
doaj   +3 more sources