Results 111 to 120 of about 870,132 (295)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Findlay Market photograph

, 1935
This image is a view of Findlay Market, located at the corner of Race and Elder Streets in Cincinnati, Ohio. Visible in the photograph are a vendor’s table, packing crates, passersby, and nearby storefronts. Findlay Market is the state’s oldest surviving
Works Progress Administration
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A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Assessing Agricultural Reuse Potential of Treated Wastewater: A Hybrid Machine Learning Approach

Agronomy
Estimating the quality of treated wastewater is a complex, nonlinear challenge that traditional statistical methods struggle to address. This study introduces a hybrid machine learning approach to predict key effluent parameters from an advanced ...
Daniyal Durmuş Köksal, Yeşim Ahi, Mladen Todorovic   +2 more
doaj   +1 more source

[Provincia de Buenos Aires, Engine Drawing Card, Sketch No. 7856]

, 1926
This engine drawing card was created for Compania General de Ferrocarriles en la Provincia de Buenos Aires, Class 12-3-28 E. Section H-12 E. Sketch 7856. Copy Spec.
Baldwin Locomotive Works
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

USING OF DERIVATE- GRAPHICAL ANALYSIS FOR INVESTIGATION OF EFFICIENCY OF EXOTHERMAL REACTIONS IN THE PROCESSES OF PROFITABLE FEEDING OF CASTING

Литьë и металлургия, 2009
It is determined that derivate-graphic analysis gives possibility to investigate efficiency of exothermal reactions in the process of profitable feeding of castings.
D. M. Kukuj, Ju. N. Fasevich, V. V. Shevchuk, A. I. Turok   +3 more
doaj  

Bologna Città 30. Experiences and perspectives

TeMA: Journal of Land Use, Mobility and Environment
Bologna is the first major Italian city to become a ‘30 km/h City’, following the example of many other European cities. Since its launch in 2022, the ‘Bologna Città 30’ Plan has marked the beginning of a technical process, culminating in the approval of
Valentina Orioli, Luca Bellinato, Cleto Carlini   +2 more
doaj   +1 more source

[Ferrocarril Provincial de Buenos Aires, Argentine, Engine Drawing Card, Sketch No. 7889]

, 1927
This engine drawing card was created for Compania General de Ferrocarriles en la Provincia de Buenos Aires, Class 12-28 1/4 D. Section H-12 1/4 D. Sketch 7889. Copy Spec.
Baldwin Locomotive Works
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source