Results 91 to 100 of about 728,983 (245)
Bologna Città 30. Experiences and perspectives
TeMA: Journal of Land Use, Mobility and EnvironmentBologna is the first major Italian city to become a ‘30 km/h City’, following the example of many other European cities. Since its launch in 2022, the ‘Bologna Città 30’ Plan has marked the beginning of a technical process, culminating in the approval of
Valentina Orioli +2 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Литьë и металлургия, 2009 It is determined that derivate-graphic analysis gives possibility to investigate efficiency of exothermal reactions in the process of profitable feeding of castings.
D. M. Kukuj +3 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Metalurgija, 2019 Three dimensional model of 350 MW utility boiler furnace was established by CFD to explore the combustion characteristics of pulverized coal at different O2 / CO2 ratios. The temperature field, sub-concentrations distributions, burner wall heat loads and
X. M. Wang, X. L. Wu, W. Q. Zhou
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Questions of the general psychology in works of Mashkhur Zhusup Kopeyev
Хабаршы. Психология және социология сериясы, 2017 This article is devoted to the analysis of questions of the general psychology in works of Mashkhur Zhusup Kopeyev. Development of psychological views of Mashkhur Zhusup Kopeyev represents very actual task.
A. A. Bizhanova
doaj +2 more sources