Results 71 to 80 of about 13,654,241 (290)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Hydrodynamic Modeling for Enhance Water System in Katingan Tidal Lowlands
Jurnal Teknik PengairanA study was conducted on the Katingan tidal lowland area with hydro-topography A and B. The lowland area has good irrigation capability but low drainage capability, resulting in excessive inundation.
Insanul Kamil +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Journal of the Civil Engineering Forum, 2013 City of Surakarta, known as Solo City is one of cities in Central Java Province traversed by Bengawan Solo River. Heavy rainfall in upstream area of Bengawan Solo River causes increase in high water level at downstream. Bengawan Solo River will be higher
Ali Trusharyanto +2 more
doaj +1 more source
The hidden work of general practitioners: An ethnography
Social Science & MedicineHigh quality primary care is a foundational element of effective health services. Internationally, primary care physicians (general practitioners (GPs), family doctors) are experiencing significant workload pressures. How non-patient-facing work contributes to these pressures and what constitutes this work is poorly understood and often unrecognised ...
Rachel Barnard +5 more
openaire +4 more sources
Social Work in General Practice [PDF]
BMJ, 1958 Considerable interest to-day is focused on the treat ment and management of stress and strain and emotional disturbance in general practice. Opinions vary regarding the extent and importance of this prob lem, but few would deny that the family doctor, whether he likes it or not, is faced with a variety of social and emotional problems on which patients
openaire +2 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A Comparative Study of the General Health among Staff Nurses with Fixed or Rotating Working Shift
نشریه پرستاری ایران, 2007 Introduction and Aim: Long time working shifts and its related tiredness threatens the health of staff nurses in various dimensions. If nurses don’t experience a good general health, they would not be able to deliver good patient care.
M .A. Soleimany +3 more
doaj
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source