Results 121 to 130 of about 6,390,037 (338)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Analysis of oxygen enriched combustion characteristic of 350 MW utility boiler based on computational fluid dynamics

Metalurgija, 2019
Three dimensional model of 350 MW utility boiler furnace was established by CFD to explore the combustion characteristics of pulverized coal at different O2 / CO2 ratios. The temperature field, sub-concentrations distributions, burner wall heat loads and
X. M. Wang, X. L. Wu, W. Q. Zhou
doaj  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Willoughby, Percival Robert Augustus, (14 May 1868–1 May 1913), Director of Public Works, Jamaica, British West Indies; official member of Legislative Council of the Colony of Jamaica; ex officio Member of the Kingston General Commissioners

, 2007

openalex   +1 more source

The Chingizid States in the Works of General G.E. Katanaev

, 2023
G Katanaev, Nikolay Lapin, Kuanysh Akanov, ;, ;, ;, , , ; -, , ;, Abil, Baskhanov, M Baskhanov, Kudryashev Doroshenko, O -Doroshenko, V Kudryashev, G Trudy, Kalieva, Zh Kalieva, Katanaev, G Katanaev, G Katanaev ; Katanaev, ; Katanaev, G A -Katanaev, G Katanaev ; Katanaev, Sokova Kruzhinov, ; -Kruzhinov, V Sokova, Z, Kruzhinov, V Sokova ; -Kruzhinov, Z Sokova, Losunov, A Losunov, Mukataeva, L Sultangazy ; -Mukataeva, G Sultangazy, F Saprygin ; Saprygin, V Trepavlov ; Trepavlov, V Trepavlov ; Trepavlov, ;, A ;, ;,   +44 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Questions of the general psychology in works of Mashkhur Zhusup Kopeyev

Хабаршы. Психология және социология сериясы, 2017
This article is devoted to the analysis of questions of the general psychology in works of Mashkhur Zhusup Kopeyev. Development of psychological views of Mashkhur Zhusup Kopeyev represents very actual task.
A. A. Bizhanova
doaj   +2 more sources

On Expediency of Dividing Public Needs in the Sphere of Purchases of Goods, Works and Services into General and Intra-Organizational Ones

, 2019
V. V. Kikavets
openalex   +1 more source

ENGLISH LANGUAGE: GENERAL WORKS [PDF]

, 1949
R. M. WILSON
openalex   +1 more source